Pulse wave velocity in retinal arteries of healthy volunteers
Pulse wave velocity in retinal arteries of healthy volunteers
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DOI：
10.1136/bjo.2010.181263
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发表时间：
2011-05-01
影响因子：
4.1
通讯作者：
Lanzl, Ines M.
中科院分区：
文献类型：
--
作者：
Kotliar, Konstantin E.;Baumann, Marcus;Lanzl, Ines M.
背景/目标 大血管脉搏波速度 (PWV) 的测量已广泛用于临床实践，作为动脉僵硬度的间接测量和心血管危险因素的指标。动脉僵硬度随着年龄的增长和冠状动脉疾病而增加。开发了一种表征中央微循环动脉僵硬度的体内临床方法。方法通过动态血管分析仪在随机选择的 10 名年轻（26.0（23.5，27.0）岁（中位数（第一个四分位数，第三个四分位数））和 10 岁（67.0（61.3，69.5））岁的眼睛中检查视网膜血管直径随时间的变化 老）健康的志愿者。同时测量视网膜动脉的两段。使用视网膜照片测量片段之间的距离。使用信号分析方法对数据进行过滤和分析，以计算评估的视网膜动脉中的 PWV (rPWV)。结果 rPWV 在年轻 (21.5 (17.9, 4.6) mm/s) 和老年 (243.8 (186.1, 347.7) mm/s) 志愿者之间存在显着差异：(p=0.0001，使用 Bonferroni 进行 Mann-Whitney 测试 结论 这项研究表明老年人的 rPWV 高于年轻人。因此，这个新参数类似于大动脉 PWV。这表明中央微循环的动态体内成像能够使用市售医疗设备测量局部微血管硬度。
Background/aims Measurement of pulse wave velocity (PWV) in large vessels has been used extensively in clinical practice as an indirect measure of arterial stiffness and an indicator of cardiovascular risk factors. Arterial stiffness increases with age and in coronary artery disease. An in vivo clinical method to characterise arterial stiffness of the central microcirculation was developed.Methods Time-dependent alterations of retinal vessel diameter were examined by the dynamic vessel analyzer in a randomly chosen eye of 10 young (26.0 (23.5, 27.0) years old (median (1st quartile, 3rd quartile)) and 10 old (67.0 (61.3, 69.5)) years old) healthy volunteers. Two segments of a retinal artery were measured simultaneously. The distance between the segments was measured using retinal photographs. The data were filtered and analysed using signal analysis methods in order to calculate PWV in the assessed retinal artery (rPWV).Results rPWV differed significantly between young (21.5 (17.9, 4.6) mm/s) and old (243.8 (186.1, 347.7) mm/s) volunteers: (p=0.0001, Mann-Whitney test with Bonferroni correction).Conclusions This study demonstrates a higher rPWV in elderly people than in young people. Therefore this new parameter resembles large artery PWV. This suggests that dynamic in vivo imaging of the central microcirculation enables the measurement of local microvascular stiffness with a commercially available medical device.