Repurposing Albendazole: new potential as a chemotherapeutic agent with preferential activity against HPV-negative head and neck squamous cell cancer.
Repurposing Albendazole: new potential as a chemotherapeutic agent with preferential activity against HPV-negative head and neck squamous cell cancer.
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DOI：
10.18632/oncotarget.17292
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发表时间：
2017-09-22
期刊：
影响因子：
--
通讯作者：
Nichols AC
中科院分区：
文献类型：
--
作者：
Ghasemi F;Black M;Vizeacoumar F;Pinto N;Ruicci KM;Le CCSH;Lowerison MR;Leong HS;Yoo J;Fung K;MacNeil D;Palma DA;Winquist E;Mymryk JS;Boutros PC;Datti A;Barrett JW;Nichols AC
Albendazole is an anti-helminthic drug that has been shown to exhibit anti-cancer properties, however its activity in head and neck squamous cell cancer (HNSCC) was unknown. Using a series of in vitro assays, we assessed the ability of albendazole to inhibit proliferation in 20 HNSCC cell lines across a range of albendazole doses (1 nM–10 μM). Cell lines that responded to treatment were further examined for cell death, inhibition of migration and cell cycle arrest. Thirteen of fourteen human papillomavirus-negative HNSCC cell lines responded to albendazole, with an average IC50 of 152 nM. In contrast, only 3 of 6 human papillomavirus-positive HNSCC cell lines responded. Albendazole treatment resulted in apoptosis, inhibition of cell migration, cell cycle arrest in the G2/M phase and altered tubulin distribution. Normal control cells were not measurably affected by any dose tested. This study indicates that albendazole acts to inhibit the proliferation of human papillomavirus-negative HNSCC cell lines and thus warrants further study as a potential chemotherapeutic agent for patients suffering from head and neck cancer.
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影响因子：
3.8
作者：
Pourgholami MH;Cai ZY;Badar S;Wangoo K;Poruchynsky MS;Morris DL
通讯作者：
Morris DL
DOI：
10.1002/jbm.b.32908
发表时间：
2013-08-01
影响因子：
3.4
作者：
Liu, Yang;Wang, Xiao-qing;Zhang, Xue-nong
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Zhang, Xue-nong
影响因子：
3
作者：
Pourgholami, Mohammad H.;Szwajcer, Michael;Links, Matthew
通讯作者：
Links, Matthew
DOI：
10.1016/0169-4758(90)90227-u
发表时间：
1990-04-01
期刊：
PARASITOLOGY TODAY
影响因子：
--
作者：
LACEY, E
通讯作者：
LACEY, E
影响因子：
2.6
作者：
Nichols, A. C.;Palma, D. A.;Barrett, J. W.
通讯作者：
Barrett, J. W.