Chitosan-g-PLGA copolymer as a thermosensitive membrane
Chitosan-g-PLGA copolymer as a thermosensitive membrane
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DOI：
10.1016/j.carbpol.2009.12.021
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发表时间：
2010-05-05
影响因子：
11.2
通讯作者：
Abdekhodaie, Mohammad J.
中科院分区：
文献类型：
--
作者：
Ganji, Fariba;Abdekhodaie, Mohammad J.
将聚(丙交酯-乙交酯)共聚物(PLGA)接枝到壳聚糖膜表面，合成了一种温敏性共聚物。以丙烯酰氯为偶联剂，将PLGA共价连接到壳聚糖膜上。用红外光谱和差示扫描量热仪对接枝共聚物进行了表征。研究了共聚物的热敏溶胀行为。膜表现出可逆的溶胀-收缩行为；在较高的温度下可获得较高的溶胀率。以盐酸万古霉素和倍他米松磷酸钠为模型药物进行药物渗透研究。万古霉素的渗透系数是温度的不连续函数；膜的渗透系数在膜的上临界溶液温度(UCST)以上急剧增加。考虑到壳聚糖与PLGA具有良好的生物相容性，这些温敏性壳聚糖接枝PLGA膜可用于开发智能给药系统。(C)2009爱思唯尔有限公司。保留所有权利。
A thermosensitive copolymer was synthesized by graft copolymerization of poly(lactide-co-glycolide) (PLGA) copolymers onto the surface of chitosan membranes. Acryloyl chloride was used as a coupling reagent for the covalent attachment of PLGA to the chitosan membranes. FTIR spectroscopy and DSC analysis were used to characterize the resulting graft copolymer. Thermosensitive swelling behaviors of the copolymer were investigated as well. The membranes exhibited reversible swelling-shrinking behavior; higher swelling ratios were obtained observed at higher temperatures. Drug permeation studies were carried out using vancomycin hydrochloride and betamethasone sodium phosphate as the model drugs. The permeability coefficient of vancomycin was found to be a discontinuous function of temperature; the permeability increased steeply above the upper critical solution temperature (UCST) of the membranes. Considering the high biocompatibility of chitosan and PLGA, these thermosensitive chitosan-g-PLGA membranes might be used to develop an intelligent drug delivery system. (C) 2009 Elsevier Ltd. All rights reserved.