IMMEDIATE AND SUSTAINED HEMODYNAMIC AND CLINICAL IMPROVEMENT IN CHRONIC HEART-FAILURE BY AN ORAL ANGIOTENSIN-CONVERTING ENZYME-INHIBITOR
IMMEDIATE AND SUSTAINED HEMODYNAMIC AND CLINICAL IMPROVEMENT IN CHRONIC HEART-FAILURE BY AN ORAL ANGIOTENSIN-CONVERTING ENZYME-INHIBITOR
复制标题
DOI：
10.1161/01.cir.61.5.931
复制
发表时间：
1980-01-01
期刊：
影响因子：
37.8
通讯作者：
PARMLEY, W
中科院分区：
文献类型：
--
作者：
ADER, R;CHATTERJEE, K;PARMLEY, W
在 10 名有症状的慢性充血性心力衰竭患者中评估了口服血管紧张素转换酶抑制剂卡托普利的血流动力学影响。所有患者的心输出量（平均 28%）、每搏输出量（平均 28%）、每搏输出量（49%）和每搏做功指数（26%）均显着增加，同时肺毛细血管楔压（48%）降低，表明左心室功能得到改善。观察到心率和动脉压适度下降。 7 名维持卡托普利治疗的患者在 2 个月时重复进行血流动力学研究。显示出持续的影响。这些有益的血流动力学效应伴随着维持治疗期间的临床改善和运动耐量的改善。卡托普利可能是慢性充血性心力衰竭患者长期治疗的有用治疗辅助药物。
The hemodynamic effects of an oral angiotensin-converting enzyme inhibitor, captopril, were evaluated in 10 symptomatic patients with chronic congestive heart failure. In all patients there was a significant increase in cardiac output (average 28%), stroke volume (49%) and stroke work index (26%) along with a decrease in pulmonary capillary wedge pressure (48%) indicating improved left ventricular function. Modest decreases in heart rate and arterial pressure were observed. In 7 patients maintained on captopril therapy repeat hemodynamic studies at 2 mo. revealed sustained effects. These beneficial hemodynamic effects were accompanied by clinical improvement and improved exercise tolerance during maintenance therapy. Captopril may be a useful therapeutic adjunct for the long-term management of patients with chronic congestive heart failure.