Maternal occupation in agriculture and risk of limb defects in Washington State, 1980-1993
Maternal occupation in agriculture and risk of limb defects in Washington State, 1980-1993
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DOI：
10.5271/sjweh.531
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发表时间：
2000-06-01
影响因子：
6.3
通讯作者：
Schwartz, SM
中科院分区：
文献类型：
--
作者：
Engel, LS;O'Meara, ES;Schwartz, SM
Objectives本研究探讨了母亲职业暴露于农业化学品与后代肢体缺陷风险之间的关系。方法采用华盛顿州1980年至1993年出生记录进行回顾性队列研究。暴露组，包括4466出生的母亲从事农业，比较了两个参考组：（一）23512出生的父母都不从事农业（“非农业”组）和（二）5994出生的只有父亲从事农业（“父亲农业”组）。关注的结果是肢体缺陷[并指、多指、缺指和“其他肢体减少”]结果与非农业组和父亲农业组相比，接触组肢体缺陷的风险增加，种族调整的患病率比为2.6 [95%置信区间（95% CI）1.1-5.8]和2.6（95% CI 0.7-9.5），结论这些结果支持这一假设，即母亲职业接触农药可能会增加分娩的风险，有肢体缺陷的孩子
Objectives This study examined the association between maternal occupational exposure to agricultural chemicals and the risk of limb defects among offspring.Methods A retrospective cohort study was conducted using Washington State birth records for the years 1980 through 1993. The exposed group, consisting of 4466 births to mothers employed in agriculture, was compared with 2 reference groups: (i) 23 512 births in which neither parent worked in agriculture ("nonagricultural" group) and (ii) 5994 births in which only the father worked in agriculture ("paternal agriculture" group). The outcome of interest was limb defects [syndactyly, polydactyly, adactyly, and "other limb reductions" (as listed in the birth record)].Results An elevated risk of limb defects was observed for the exposed group in comparison with both the nonagricultural and paternal agriculture groups, with ethnicity-adjusted prevalence ratios of 2.6 [95% confidence interval (95% CI) 1.1-5.8] and 2.6 (95% CI 0.7-9.5), respectively.Conclusions These results support the hypothesis that maternal occupational exposure to agricultural chemicals may increase the risk of giving birth to a child with limb defects.