Acquisition and long-term retention of spatial learning in the human immunodeficiency virus-1 transgenic rat: effects of repeated nicotine treatment.
Acquisition and long-term retention of spatial learning in the human immunodeficiency virus-1 transgenic rat: effects of repeated nicotine treatment.
复制标题
人类免疫缺陷病毒1转基因大鼠空间学习的获得和长期保留：重复尼古丁治疗的影响。
DOI：
10.1007/s13365-013-0154-1
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发表时间：
2013
影响因子：
3.2
通讯作者：
Chang,SulieL
中科院分区：
文献类型：
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作者：
Vigorito,Michael;Cao,Junran;Li,MingD;Chang,SulieL
与转基因同窝大鼠和 F344 对照大鼠相比，HIV-1 转基因 (HIV-1Tg) 大鼠在多次试验水迷宫任务中学习定位水下平台方面存在缺陷（Vigorito 等人，J.Neuroimmune Pharmacol2:319–328, 2007；Lashomb 等人，J.Neurovirol15:14–24, 2009）。已知尼古丁可能通过最小化谷氨酸的细胞毒性作用或通过调节胆碱能抗炎途径而具有神经保护作用。尼古丁还可以通过增强注意力和短期记忆（STM）来提高各种学习任务的表现。本研究的目的是确定反复尼古丁治疗是否可以改善 HIV-1Tg 的学习缺陷，而与尼古丁对 STM 的影响无关。 HIV-1Tg 和 F344 大鼠每天两次用尼古丁（0.25 mg/kg/注射）或盐水治疗（皮下），并在每天一次试验的程序中进行测试，以排除 STM 对获得空间学习任务的影响。在探针测试中，HIV-1Tg 大鼠在获得任务和长期保留平台位置方面表现出缺陷。尼古丁并没有改善 HIV-1Tg 大鼠的缺陷，并且在获得过程中表现略有恶化。对探针测试期间表现的个体差异的分析表明，尼古丁改善了一些 F344 大鼠的表现，但没有改善 HIV-1Tg 大鼠的表现。这些结果表明，长期记忆巩固的缺陷导致了 HIV1-Tg 大鼠的习得缺陷。然而，结果并没有提供任何证据表明至少在测试的尼古丁剂量下，该行为模型中观察到的学习缺陷有所改善。
The HIV-1 transgenic (HIV-1Tg) rat shows a deficit in learning to locate a submerged platform in a multiple-trial water maze task compared to transgenic littermate and F344 control rats (Vigorito et al.,J.Neuroimmune Pharmacol2:319–328, 2007; Lashomb et al.,J.Neurovirol15:14–24, 2009). Nicotine is known to have neuroprotective effects possibly by minimizing cytotoxic effects of glutamate or by modulating a cholinergic anti-inflammatory pathway. Nicotine also improves performance in a variety of learning tasks by enhancing attention and short-term memory (STM). The purpose of this study was to determine if the learning deficit in HIV-1Tg is ameliorated by repeated nicotine treatment independent of its effects on STM. HIV-1Tg and F344 rats were treated (subcutaneous) with nicotine (0.25 mg/kg/injection) or saline twice daily and tested in a single-trial-per-day procedure which precludes the impact of STM on the acquisition of the spatial learning task. HIV-1Tg rats showed a deficit in the acquisition of the task and in the long-term retention for the platform location in a probe test. Nicotine did not ameliorate the deficit in HIV-1Tg rats and slightly worsened performance during acquisition. Analysis of individual differences in performance during the probe test suggested that nicotine improved performance in some F344 rats but not in HIV-1Tg rats. These results indicate that a deficit in the consolidation of long-term memory contributes to the acquisition deficit of HIV1-Tg rats. The results, however, do not provide any evidence of the amelioration of the learning deficit observed in this behavioral model at least with the nicotine dose tested.