Focal glomerulosclerosis in obese zucker rats and prevention of its development.
Focal glomerulosclerosis in obese zucker rats and prevention of its development.
复制标题
肥胖 zucker 大鼠的局灶性肾小球硬化及其发展的预防。
DOI：
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发表时间：
1983
期刊：
影响因子：
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通讯作者：
T. Shimamura
中科院分区：
文献类型：
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作者：
T. Shimamura
遗传性肥胖的Zucker大鼠患上一种自发性肾小球疾病。这种病变的发生机制尚不清楚。因此，我们用光学显微镜和肾单位解剖技术检查了肾脏的结构变化。肾小球病变为局灶性节段性硬化症，伴有肾小球增大和集合管及连接管腔的明显扩张。这些肥胖大鼠减少饮食摄入量可防止肾小球肿大、肾小球硬化和肾小管扩张。肾小球硬化的发生可能与肾小球肥大有关。此外，集合管和连接管明显扩张，但无下尿路梗阻迹象，提示有肾小管梗阻。
Genetically obese Zucker rats develop a spontaneous glomerular disease. The mechanism of development of this lesion is poorly understood. We therefore examined structural alterations of the kidneys by light microscopy and by use of nephron dissection technique. The glomerular lesion was a focal segmental sclerosis that developed in association with glomerular enlargement and with prominent dilation of collecting and connecting tubular lumina. Reduction of dietary intake in these obese rats prevented the emergence of glomerulomegaly, glomerulosclerosis, and tubular dilation. The development of the glomerulosclerosis might be related to glomerulomegaly. In addition, the prominent dilation of collecting and connecting tubules without evidence of obstruction of lower urinary tract indicated that there was intrarenal tubular obstruction.