Tumor apelin, not serum apelin, is associated with the clinical features and prognosis of gastric cancer.
Tumor apelin, not serum apelin, is associated with the clinical features and prognosis of gastric cancer.
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DOI：
10.1186/s12885-016-2815-y
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发表时间：
2016-10-12
期刊：
影响因子：
3.8
通讯作者：
Wang K
中科院分区：
文献类型：
--
作者：
Feng M;Yao G;Yu H;Qing Y;Wang K
研究Apelin表达与胃癌患者的临床特征和术后预后之间的关系（Int J Cancer 136：2388-2401，2015）。从270例接受手术切除的GC患者中收集肿瘤样本和匹配的邻近正常组织。分别采用免疫组化法和ELISA法检测肿瘤和血清Apelin水平。培养GC细胞系用于迁移和侵袭性测定。我们的数据显示肿瘤Apelin表达状态而不是血清Apelin水平与更高级的临床特征包括肿瘤分化、淋巴结和远处转移密切相关。此外，具有高肿瘤Apelin水平的患者与具有低Apelin表达的患者和具有或阴性Apelin染色的患者相比具有显著更短的总生存期。我们的体外研究显示Apelin调节GC细胞系的迁移和侵袭能力，伴随着与肿瘤侵袭相关的多种细胞因子的上调。我们的数据表明，肿瘤Apelin可以作为一个标志物，以评估胃癌患者的临床特征和预测预后。
To study the association between Apelin expression and the clinical features and postoperative prognosis in patients with gastric cancer (Int J Cancer 136:2388-2401, 2015). Tumor samples and matched adjacent normal tissues were collected from 270 patients with GC receiving surgical resection. The tumor and serum Apelin levels were determined by immunohistochemistry and ELISA methods, respectively. GC cell lines were cultured for migration and invasive assays. Our data showed that tumor Apelin expression status, instead of serum Apelin level, was closely associated with more advance clinical features including tumor differentiation, lymph node and distant metastases. Moreover, patients with high tumor Apelin level had a significantly shorter overall survival period compared to those with low Apelin expression and those with or negative Apelin staining. Our in vitro study revealed that the Apelin regulated the migration and invasion abilities of GC cell lines, accompanied by up-regulations of a variety of cytokines associated with tumor invasiveness. Our data suggest that tumor Apelin can be used as a marker to evaluate clinical characteristics and predict prognosis in GC patients.
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