Tumor-associated macrophages predict prognosis in diffuse large B-cell lymphoma and correlation with peripheral absolute monocyte count
Tumor-associated macrophages predict prognosis in diffuse large B-cell lymphoma and correlation with peripheral absolute monocyte count
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肿瘤相关巨噬细胞预测弥漫性大 B 细胞淋巴瘤的预后及其与外周绝对单核细胞计数的相关性
DOI：
10.1186/s12885-019-6208-x
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发表时间：
2019-11-06
期刊：
影响因子：
3.8
通讯作者：
Zhai, Zhi-Min
中科院分区：
文献类型：
--
作者：
Li, Yan-Li;Shi, Zhi-Hu;Zhai, Zhi-Min
背景弥漫性大B细胞淋巴瘤(DLBCL)具有临床和生物学异质性的特点。肿瘤相关巨噬细胞(TAMS)在DLBCL中的临床预后意义仍存在争议，TAMS与外周血绝对单核细胞计数(AMC)的相关性尚未阐明。方法对221例初治、初诊的DLBCL患者进行免疫组织化学分析，评价TAMS的预后价值以及TAMS与AMC的相关性。结果CD68高表达或CD163高表达与DLBCL的临床病理特征相关，CD163高表达对DLBCL患者的总生存期(OS)[风险比(HR)=2.265，P=0.005]和无进展生存期(PFS)(HR=1.925，P=0.017)均有不良预测作用。CD68高表达和CD163高表达患者的OS和PFS分别显著低于CD68低表达和CD163低表达患者(CD68：OS：P
Background Diffuse large B-cell lymphoma (DLBCL) is characterized by its clinical and biological heterogeneity. The clinical prognostic implications of tumor-associated macrophages (TAMs) in DLBCL remain controversial and the correlation between TAMs and peripheral absolute monocyte count (AMC) has not yet been elucidated. Methods In 221 untreated, newly diagnosed patients with DLBCL, we evaluated the prognostic value of TAMs using immunohistochemical analysis, as well as the association of TAMs and AMC. Results We found that high CD68 or high CD163 expression was correlated with clinicopathological characteristics, high CD163 expression was an adverse predictor for both overall survival (OS) [hazard ratio (HR) = 2.265, P = 0.005] and progression- free survival (PFS) (HR = 1.925, P = 0.017) in patients with DLBCL. Patients with high CD68 or high CD163 expression had significantly poorer OS and PFS than those with low CD68 or low CD163 expression, respectively (CD68: OS: P