World Workshop on Oral Medicine VI: clinical implications of medication-induced salivary gland dysfunction
World Workshop on Oral Medicine VI: clinical implications of medication-induced salivary gland dysfunction
复制标题
DOI：
10.1016/j.oooo.2014.10.027
复制
发表时间：
2015-08-01
影响因子：
2.9
通讯作者：
Vissink, Arjan
中科院分区：
文献类型：
--
作者：
Aliko, Ardita;Wolff, Andy;Vissink, Arjan
Objective.本研究的目的是系统地回顾现有文献的药物诱导的唾液腺功能障碍（MISGD）的临床意义。使用PubMed、Embase和Web of Science（截至2013年6月）进行系统性综述。根据MISGD的临床意义是否是主要研究结果以及研究设计和样本量的适当性，对研究的相关程度和证据强度进行评估。对于大多数声称的致干燥药物，口干是最常见的不良反应。在129篇综述文献中，大多数文献未记录口干症是否伴有唾液流量减少。药物引起的口干症的发病率和患病率变化很大，通常与药物的数量和剂量有关。最常报告的口干症严重程度为轻度至中度。其发作通常发生在治疗的前几周。有选择的证据表明，药物诱导的口干症更常见于女性和老年人，MISGD可能与其他临床意义，如龋齿或口腔粘膜改变。系统性综述表明，MISGD对许多患者构成了重大负担，可能与口腔健康的重要负面影响有关。
Objective. This study aimed to systematically review the available literature on the clinical implications of medication-induced salivary gland dysfunction (MISGD).Study Design. The systematic review was performed using PubMed, Embase, and Web of Science (through June 2013). Studies were assessed for degree of relevance and strength of evidence, based on whether clinical implications of MISGD were the primary study outcomes, as well as on the appropriateness of study design and sample size.Results. For most purported xerogenic medications, xerostomia was the most frequent adverse effect. In the majority of the 129 reviewed papers, it was not documented whether xerostomia was accompanied by decreased salivary flow. Incidence and prevalence of medication-induced xerostomia varied widely and was often associated with number and dose of medications. Xerostomia was most frequently reported to be mild-to-moderate in severity. Its onset occurred usually in the first weeks of treatment. There was selected evidence that medication-induced xerostomia occurs more frequently in women and older adults and that MISGD may be associated with other clinical implications, such as caries or oral mucosal alterations.Conclusions. The systematic review showed that MISGD constitutes a significant burden in many patients and may be associated with important negative implications for oral health.