Early and late onset Alzheimer's disease patients have distinct patterns of white matter damage
Early and late onset Alzheimer's disease patients have distinct patterns of white matter damage
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DOI：
10.1016/j.neurobiolaging.2010.09.021
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发表时间：
2012-06-01
影响因子：
4.2
通讯作者：
Filippi, Massimo
中科院分区：
文献类型：
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作者：
Canu, Elisa;Frisoni, Giovanni B.;Filippi, Massimo
我们研究了 18 名早发 (EO) 和 24 名晚发 (LO) 阿尔茨海默病 (AD) 患者与 42 名健康对照 (HC) 的白质 (WM) 丢失模式，并探讨了 WM 萎缩与载脂蛋白 E (ApoE) 基因型的关系。受试者接受了磁共振成像 (MRI)。使用基于体素的形态测量法评估 WM 模式。与健康对照相比，LOAD 患者存在选择性海马旁 WM 丢失，而 EOAD 患者则经历更广泛的后部 WM 萎缩模式。 WM 萎缩的独特区域分布反映了灰质 (GM) 损失的分布情况。在两个 AD 组中，ApoE epsilon 4 状态与海马旁 WM 损失更大有关。 EOAD 中的 WM 萎缩程度比 LOAD 中的 WM 萎缩程度更大，这符合 EOAD 是一种更具侵袭性的疾病形式的证据。 ApoE epsilon 4 对 AD 中 WM 损伤的影响仅限于特定的 WM 区域，并且似乎与发病年龄无关。 (C) 2012 Elsevier Inc. 保留所有权利。
We investigated patterns of white matter (WM) loss in 18 early onset (EO) and 24 late onset (LO) Alzheimer's disease (AD) patients compared with 42 healthy controls (HC), and explored relationships of WM atrophy and apolipoprotein E (ApoE) genotype. Subjects underwent magnetic resonance imaging (MRI). Patterns of WM were assessed using voxel-based morphometry. Compared with healthy controls, LOAD patients had a selective parahippocampal WM loss, while EOAD patients experienced a more widespread pattern of posterior WM atrophy. The distinct regional distribution of WM atrophy reflected the topography of gray matter (GM) loss. ApoE epsilon 4 status was associated with a greater parahippocampal WM loss in both AD groups. The greater WM atrophy in EOAD than LOAD fits with the evidence that EOAD is a more aggressive form of the disease. The ApoE epsilon 4 effect on WM damage in AD is restricted to specific WM regions and does not seem to be related to age of onset. (C) 2012 Elsevier Inc. All rights reserved.