Functional deficiencies of subsarcolemmal mitochondria in the type 2 diabetic human heart
Functional deficiencies of subsarcolemmal mitochondria in the type 2 diabetic human heart
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DOI：
10.1152/ajpheart.00845.2013
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发表时间：
2014-07-01
影响因子：
4.8
通讯作者：
Hollander, John M.
中科院分区：
文献类型：
--
作者：
Croston, Tara L.;Thapa, Dharendra;Hollander, John M.
The mitochondrion has been implicated in the development of diabetic cardiomyopathy. Examination of cardiac mitochondria is complicated by the existence of spatially distinct subpopulations including subsarcolemmal (SSM) and interfibrillar (IFM). Dysfunction to cardiac SSM has been reported in murine models of type 2 diabetes mellitus; however, subpopulationbased mitochondrial analyses have not been explored in type 2 diabetic human heart. The goal of this study was to determine the impact of type 2 diabetes mellitus on cardiac mitochondrial function in the human patient. Mitochondrial subpopulations from atrial appendages of patients with and without type 2 diabetes were examined. Complex I-and fatty acid-mediated mitochondrial respiration rates were decreased in diabetic SSM compared with nondiabetic (P
