Different maternal serum hCG levels in pregnant women with female and male fetuses: does fetal hypophyseal adrenal gonadal axis play a role?
Different maternal serum hCG levels in pregnant women with female and male fetuses: does fetal hypophyseal adrenal gonadal axis play a role?
复制标题
DOI：
10.1515/jpm.2004.064
复制
发表时间：
2004-01-01
影响因子：
2.4
通讯作者：
Demir, N
中科院分区：
文献类型：
--
作者：
Gol, M;Altunyurt, S;Demir, N
胎儿性别对母血和脐血hCG水平有显著影响，特别是在妊娠的最后三个月。然而，造成这种差异的原因尚不清楚。本研究的目的是探讨足月胎儿垂体、肾上腺、性腺轴是否存在性别差异，从而导致hCG水平的差异。这项研究包括60名怀孕晚期单胎妊娠的妇女。31名孕妇怀的是女性胎儿，而29名怀孕的是男性。测定母血和脐血中人绒毛膜促性腺激素(HCG)、雌二醇、孕酮、睾酮、脱氢表雄酮硫酸盐(DHEAS)、催乳素和生长激素水平。
Fetal gender has a significant effect on maternal and cord blood hCG levels, particularly during the last trimester of the pregnancy. However, the reason for this difference is obscure. The aim of the present study was to investigate whether term fetal hypophyseal adrenal gonadal axis differs between female and male fetuses thereby causing different hCG levels. The study consisted of 60 women with singleton pregnancies in the third trimester. Thirtyone pregnant women were carrying female fetuses, whereas 29 were carrying male. Human chorionic gonadotropin (hCG), estradiol, progesterone, testosterone, dehydroepiandrosteronsulfate (DHEAS), prolactin and growth hormone levels were measured in maternal serum and umbilical cord blood.In female bearing pregnancies maternal and cord blood hCG levels were significantly higher than in male bearing pregnancies (P