EFFECT OF HYPOTHYROIDISM INDUCED BY PROPYLTHIOURACIL AND THIOUREA ON MALE AND FEMALE REPRODUCTIVE SYSTEMS OF NEONATAL MICE
EFFECT OF HYPOTHYROIDISM INDUCED BY PROPYLTHIOURACIL AND THIOUREA ON MALE AND FEMALE REPRODUCTIVE SYSTEMS OF NEONATAL MICE
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DOI：
10.1002/jez.1402730209
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发表时间：
1995-10-01
影响因子：
--
通讯作者：
NG, TB
中科院分区：
文献类型：
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作者：
CHAN, WY;NG, TB
研究了6-丙基-2-硫脲（PTU）和硫脲（TU）诱导的甲状腺功能减退对雄性和雌性新生ICR小鼠生殖系统发育的影响。实验动物从出生后第1天（PD1）起皮下注射PTU或TU。在PD 14、21、28日观察小鼠生殖器官组织学变化、卵泡形成及精子发生情况，并观察甲状腺功能减退小鼠成年期的生育情况。我们发现PTU或TU治疗对新生儿子宫和输卵管的组织学没有影响。相反，药物诱导卵巢原始卵泡、多层卵泡和霰粒卵泡数量减少。滤泡细胞变性的卵泡增多。在睾丸中，PTU和TU处理均导致精管数量减少，但精管的平均直径和睾丸、附睾、精囊和凝固腺的组织学未受影响。甲状腺功能低下的雌性与甲状腺功能正常的雄性、甲状腺功能低下的雄性与甲状腺功能正常的雌性交配在受孕率、产仔数、后代性别比等方面均正常。后代体细胞发育正常。由此可见，对新生期小鼠卵巢和睾丸发育的阻滞作用并不严重，不足以对甲状腺功能减退动物的生殖造成不利影响。(C) 1995 Wiley-Liss, Inc。
The effect of hypothyroidism induced by 6-propyl-2-thiouracil (PTU) or thiourea (TU) on the development of the reproductive system in male and female neonatal ICR mice was investigated. PTU or TU was injected subcutaneously into experimental animals from postnatal day 1 (PD1) onward. The histological changes of the reproductive organs, formation of ovarian follicles, and spermatogenesis were examined on PD 14, 21, and 28, and the fertility of the hypothyroid mice in adulthood was followed. It was found that PTU or TU treatment did not produce an effect on the histology of the neonatal uterus and oviduct. In contrast, the drugs induced a decrease in the number of primordial follicles, multilaminar follicles, and Graafian follicles in the ovary. The number of follicles with degenerated follicular cells was increased. In the testis both PTU and TU treatments brought about a decrease in the number of seminiferous tubules with developing spermatids although the mean diameter of seminiferous tubules and the histology of the testis, epididymis, seminal vesicle, and coagulating gland was unaffected. The mating between hypothyroid females and euthyroid males and that between hypothyroid males and euthyroid females were normal with regard to the pregnancy rate, litter size, and sex ratio of offspring. The somatic growth of the resulting offspring was normal. It is concluded that the retarding effect on ovarian and testicular development in mice during neonatal period was not serious enough to adversely affect reproduction in the hypothyroid animals. (C) 1995 Wiley-Liss, Inc.