The genetic basis of cardiac function:: dissection by zebrafish (Danio rerio) screens
The genetic basis of cardiac function:: dissection by zebrafish (Danio rerio) screens
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DOI：
10.1098/rstb.2000.0629
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发表时间：
2000-07-29
影响因子：
6.3
通讯作者：
Fishman, RC
中科院分区：
文献类型：
--
作者：
Warren, KS;Wu, JC;Fishman, RC
脊椎动物的心脏在结构和功能上都不同于脊索动物的祖先。形式的遗传单位，称为“模块”，可以通过斑马鱼和小鼠的突变来识别，并且对应于最近在进化中获得的特征，例如心室或血管和心脏的内皮衬里。斑马鱼（Danio rerio）基因筛选提供了一组合理的此类基因。斑马鱼的正常心脏功能也可能被单基因突变破坏。个体突变可能会扰乱收缩性或节律的产生。主要干扰心脏收缩力的斑马鱼突变分为两大类表型：“扩张型”和“肥大型”。有趣的是，这些对应于人类心力衰竭的两种主要类型。这些早期心脏功能疾病提供了在复杂的人类心脏疾病（包括心律失常和心力衰竭）中进行检查的候选基因。
The vertebrate heart differs from chordate ancestors both structurally and functionally. Genetic units of form, termed 'modules', are identifiable by mutation, both in zebrafish and mouse, and correspond to feature recently acquired in evolution, such as the ventricular chamber or endothelial lining of the vessels and heart. Zebrafish (Danio rerio) genetic screens have provided a reasonably inclusive set of such genes. Normal cardiac function may also be disrupted by single-gene mutations in zebrafish. Individual mutations may perturb contractility or rhythm generation. The zebrafish mutations which principally disturb cardiac contractility fall into two broad phenotypic categories, 'dilated' and 'hypertrophic'. Interestingly, these correspond to the two primary types of heart failure in humans. These disorders of early cardiac function provide candidate genes to be examined in complex human heart diseases, including arrhythmias and heart failure.