Protein repellant silicone surfaces by covalent immobilization of poly(ethylene oxide)
Protein repellant silicone surfaces by covalent immobilization of poly(ethylene oxide)
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DOI：
10.1016/j.biomaterials.2004.07.068
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发表时间：
2005-05-01
期刊：
影响因子：
14
通讯作者：
Sheardown, H
中科院分区：
文献类型：
--
作者：
Chen, H;Zhang, Z;Sheardown, H
用不同分子量的钝化聚氧化乙烯（PEO）聚合物对聚二甲基硅氧烷弹性体进行表面改性，包括单官能度和双官能度。在聚甲基氢硅氧烷存在下通过酸催化平衡在表面上引入Si-H基团之后，通过铂催化的氢化硅烷化连接PEO。ATR-FTIR、X射线光电子能谱（XPS）和水接触角测试结果表明，PEO成功地接枝到了硅橡胶上。原子力显微镜和XPS表明，PEO的表面覆盖率很高，但不完全的改性表面。通过测量缓冲液和血浆中纤维蛋白原的吸附，证明了PEO改性表面的抗蛋白质性质。与对照组相比，从缓冲液到PEO改性表面的纤维蛋白原吸附减少了90%以上。(C)2004 Elsevier Ltd.保留所有权利。
Polydimethylsiloxane elastomers were surface modified with passivating polyethylene oxide (PEO) polymers of different molecular weights, both monoftinctional and bifunctional. Following the introduction of Si-H groups on the surfaces by acid catalysed equilibration in the presence of polymethylhydrosiloxane, the PEO was linked by platinum-catalyzed hydrosilylation. ATR-FTIR, X-ray photoetectron spectroscopy (XPS) and water contact angle results confirmed that the PEO was successfully grafted to the silicone rubber. Atomic force microscopy and XPS suggested that surface coverage with PEO was very high on the modified surfaces but not complete. The protein-resistant properties of the PEO-modified surfaces were demonstrated by measuring he adsorption of fibrinogen from both buffer and plasma. Fibrinogen adsorption from buffer to the PEO-modified surfaces was reduced by more than 90% compared with controls. (C) 2004 Elsevier Ltd. All rights reserved.