Colletotryptins A-F, new dimeric tryptophol derivatives from the endophytic fungus Colletotrichum sp. SC1355
Colletotryptins A-F, new dimeric tryptophol derivatives from the endophytic fungus Colletotrichum sp. SC1355
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Colletotryptins A-F，来自内生真菌 Colletotrichum sp. 的新型二聚色氨酸衍生物。
DOI：
10.1016/j.fitote.2019.104465
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发表时间：
2020-03-01
期刊：
影响因子：
3.4
通讯作者：
Wei, Xiaoyi
中科院分区：
文献类型：
--
作者：
Shao, Lulu;Wu, Ping;Wei, Xiaoyi
从内生真菌Colletotrichum sp.SC1355的固体培养物中分离得到7个新的二聚体生物碱（1-4、5a、5 b和6）。通过核磁共振波谱分析、核磁共振（GIAO）位移的量子化学计算和电子捕获检测（ECD）谱，确定了这些化合物的结构和绝对构型。这是首次报道真菌来源的甾醇二聚体。此外，对分离的化合物进行了乙酰胆碱酯酶（AchE）抑制活性的评价。
Seven new dimeric tryptophol-related alkaloids (1-4, 5a, 5b, and 6) were isolated from solid cultures of the endophytic fungus Colletotrichum sp. SC1355. The structures and absolute configurations of these compounds were determined by NMR spectroscopic analyses in combination with quantum chemical calculations of NMR (GIAO) shifts and ECD spectra. This is the first report of fungus-derived tryptophol dimers. In addition, the isolated compounds were evaluated for acetylcholinesterase (AchE) inhibitory activity.