Dynamic changes of cognitive habituation and serotonin metabolism during the migraine interval
Dynamic changes of cognitive habituation and serotonin metabolism during the migraine interval
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DOI：
10.1046/j.1468-2982.1999.019005485.x
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发表时间：
1999-06-01
期刊：
影响因子：
4.9
通讯作者：
Husstedt, IW
中科院分区：
文献类型：
--
作者：
Evers, S;Quibeldey, F;Husstedt, IW
偏头痛患者表现出一种特殊的认知过程，在间歇期失去习惯化，而通过事件相关电位(ERPs)测量发作时的习惯化正常。尚不清楚习惯化的丧失是在偏头痛间歇期发生变化，还是处于稳定状态。5-羟色胺(5-HT)代谢参与了偏头痛的病理生理过程，也参与了ERPs的产生。我们招募了14名有规律偏头痛发作的患者，以便在偏头痛间期和偏头痛发作期间重复测量视觉诱发的ERT。通过P3潜伏期分析评价认知习惯化程度，同时测定血小板5-羟色胺含量和血浆游离5-羟色胺水平。习惯化的丧失在偏头痛间歇期持续增加，在偏头痛发作时突然正常化(p<；0.05，时间序列分析)。偏头痛发作期血小板5-羟色胺含量显著降低(p<；0.03)，间歇期中期达到最大值。发作期P3潜伏期显著延长(P<0.001)，并与血小板5-羟色胺含量呈显著负相关(r=-0.44，P<；0.01)。血浆游离5-羟色胺水平无明显变化。我们的发现表明，认知习惯化的丧失在偏头痛间期持续增加，直到偏头痛发作时才恢复正常。这种现象不能归因于5-羟色胺能传递。在偏头痛发作前认知习惯有规律变化的患者中，通过分析事件相关电位来预测发作是可能的。
Migraine patients show a specific cognitive processing with a loss of habituation in the interval and a normal habituation in the attack as measured by event-related potentials (ERPs). It is unknown whether the loss of habituation changes during the migraine interval or is a stable state. Serotonin (5HT) metabolism is involved In the pathophysiology of migraine and also in the generation of ERPs. We enrolled 14 patients with regular migraine attacks in order to measure visually evoked ERTs repetitively during the migraine interval and in the migraine attack. Cognitive habituation was evaluated by analysis of P3 latency, platelet serotonin content and free serotonin plasma level were measured at the same time points. The loss of habituation increased continuously during the migraine interval and abruptly normalized in the migraine attack (p < 0.05, time series analysis). The platelet 5HT content decreased significantly in the migraine attack (p < 0.03) and was at its maximum in the middle of the interval. The P3 latency was significantly increased in the attack (p < 0.01) and was significantly inversely correlated with the platelet 5HT content (r = -0.44, p < 0.001). Free 5HT plasma levels did not show any significant change. Our findings suggest that loss of cognitive habituation continuously increases during the migraine interval until its normalization in the migraine attack. This phenomenon cannot be attributed to serotonergic transmission. In patients with regular changes of cognitive habituation before the migraine attack, it might be possible to predict the attack by analysing ERPs.