Determinants of low-risk and high-risk cervical human papillomavirus infections in montreal university students
Determinants of low-risk and high-risk cervical human papillomavirus infections in montreal university students
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DOI：
10.1097/00007435-200002000-00005
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发表时间：
2000-02-01
影响因子：
3.1
通讯作者：
Tellier, P
中科院分区：
文献类型：
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作者：
Richardson, H;Franco, E;Tellier, P
背景：以往的研究对宫颈人乳头瘤病毒（HPV）感染的性传播程度不一致。作者假设HPV感染的危险因素因HPV类型而异。目的：估计无症状女性HPV感染的患病率，并根据致瘤型和非致瘤型确定总体HPV感染和HPV感染的危险因素。研究设计：在蒙特利尔的麦吉尔大学诊所进行了一项横断面调查，收集了489名在诊所进行常规帕帕尼科拉氏试验的女学生的宫颈标本。对潜在危险因素进行问卷调查。使用一致引物（MY09/11）进行聚合酶链反应检测人乳头瘤病毒DNA，然后使用Southern blot和dot blot技术与通用探针和类型特异性探针杂交。结果：总体HPV患病率为21.8%，6.2%的女性感染低危HPV， 11.8%的女性感染高危HPV(16、18、31、33、35、39、45、51、52、56、58)，7.1%的女性感染HPV类型未知，2.7%的女性感染多型HPV。在多变量分析后，根据致癌风险，出现了性活动和HPV感染风险的两种情况。终生性交频率和终生口交伴侣数量与高致癌风险HPV感染相关；然而，低致癌风险类型的HPV感染在性活动标志物方面是不变的。结论：这些结果提示，基于致瘤性，低危和高危HPV类型之间传播的流行病学相关因素存在差异，这一发现对HPV感染和宫颈癌前体的一级预防具有重要意义。
Background: Previous studies have been inconsistent about the degree of sexual transmissibility of cervical human papillomavirus (HPV) infection. The authors hypothesize that risk factors for HPV infection vary according to HPV type.Goal: To estimate the prevalence of HPV infection in asymptomatic women and to identify risk factors for overall HPV infection and HPV infection by oncogenic and nononcogenic type.Study Design: A cross-sectional survey was conducted at the McGill University clinic in Montreal, Cervical specimens were collected from 489 female students presenting at the clinic for a routine Papanicolaou test. Data on potential risk factors was obtained by questionnaire. Human papillomavirus DNA was detected by the polymerase chain reaction using consensus primers (MY09/11) followed by hybridization with generic and type-specific probes using Southern blot and dot blot techniques,Results: The overall HPV prevalence was 21.8%, A low-risk HPV infection was found in 6.2% of the women, 11.8% had a high-risk HPV infection (types 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58), 7.1% had an unknown HPV type, and 2.7% had a multiple type infection. Two profiles emerged for sexual activity and risk of HPV infection according to oncogenic risk after multivariate analysis. Lifetime frequency of sexual intercourse and lifetime number of oral sex partners was associated with high-oncogenic-risk HPV infections; however, HPV infection with low-oncogenic-risk types was invariant with respect to markers of sexual activity.Conclusion: These results suggest that there are differences in epidemiologic correlates of transmission between low-risk and high-oncogenic-risk HPV types based on oncogenicity, This finding has important implications for primary prevention of HPV infection and cervical cancer precursors.