Exhaled air temperature in asthma: methods and relationship with markers of disease
Exhaled air temperature in asthma: methods and relationship with markers of disease
复制标题
DOI：
10.1111/j.1365-2222.2007.02663.x
复制
发表时间：
2007-03-01
影响因子：
6.1
通讯作者：
Boner, A. L.
中科院分区：
文献类型：
--
作者：
Piacentini, G. L.;Peroni, D.;Boner, A. L.
呼气温度已被建议作为评估哮喘患者呼吸道炎症的替代标志物。本研究的目的是扩展呼气温度作为一种使用专业开发的仪器评估呼吸道炎症的手段的研究。57名儿童、41名过敏性轻度哮喘患者和16名健康对照进行了评估。他们接受了呼气温度和肺功能的测量。哮喘患儿呼气温度明显高于对照组，分别为30.18±0.14摄氏度和27.47±0.24摄氏度(P<；0.001)。哮喘患儿呼出空气温度与呼出一氧化氮(r=0.39；P=0.01)、诱导痰中EOS百分比(Rho=0.53；P=0.04)呈正相关，支持呼气温度与哮喘气道炎症程度相关的假说。
Exhaled breath temperature has been proposed as a surrogate marker for the evaluation of airway inflammation in asthmatic patients.The aim of the present study was to extend the investigation of exhaled air temperature as a means for the evaluation of airway inflammation using a professionally developed instrument.Fifty-seven children, 41 allergic mild asthmatics and 16 healthy controls have been evaluated. They underwent exhaled air temperature and lung function measurement. The asthmatic children also underwent exhaled nitric oxide measurement, and hypertonic saline sputum induction for the evaluation of eosinophil (EOS) percentage.The level of exhaled temperature was significantly higher in asthmatics than in controls, being 30.18 +/- 0.14 degrees C vs. 27.47 +/- 0.24 degrees C (P < 0.001). In asthmatic children, a positive relationship was observed between exhaled air temperature and both exhaled nitric oxide (r=0.39; P=0.01) and EOS percentage in samples from induced sputum (rho=0.53; P=0.04).The data from the present study support the hypotheses that exhaled breath temperature is related to the degree of airway inflammation in asthma.