Effects of the menstrual cycle on sympathetic neural responses to mental stress in humans
Effects of the menstrual cycle on sympathetic neural responses to mental stress in humans
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DOI：
10.1113/jphysiol.2007.141051
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发表时间：
2007-12-01
影响因子：
5.5
通讯作者：
Lawrence, Johnathan E.
中科院分区：
文献类型：
--
作者：
Carter, Jason R.;Lawrence, Johnathan E.
月经周期对静息肌肉交感神经活动（MSNA）的影响仍然存在争议，月经周期对 MSNA 对精神压力反应的影响尚不清楚。我们检查了 11 名健康女性在月经周期的卵泡早期 (EF) 和黄体中期 (ML) 阶段的 MSNA、平均动脉压 (MAP) 和心率 (HR) 对精神压力的反应（通过心算）。月经周期不会改变静息 MSNA（EF，每分钟 13 +/- 3 次心跳（-1）与 ML，每分钟 13 +/- 2 次心跳（-1））、MAP（EF，79 +/- 3 mmHg 与 ML，81 +/- 2 mmHg）和 HR（EF，每分钟 66 +/- 3 次心跳（-1）与 ML，64 +/- 2 次心跳）分钟(-1))。在 EF（Delta 4 +/- 2 次突发（-1）、Delta 12 +/- 2 mmHg、Delta 18 +/- 2 次心跳（-1）；P < 0.05）和 ML（Delta 4 +/- 2 次突发（-1）、Delta 13 +/- 3 mmHg 和 Delta 20 +/- 2 次心跳）期间，5 分钟的精神压力增加了 MSNA、MAP 和 HR分钟（-1）；P < 0.05）阶段。这些反应在不同阶段没有不同。相比之下，在从精神压力恢复的 10 分钟内，不同阶段的 MSNA 反应是不同的。 MSNA 在 EF（Delta 6 +/- 1 次突发 min(-1)；P < 0.01）和 ML（Delta 7 +/- 1 次突发 min(-1)；P < 0.01）恢复的最初 5 分钟内保持升高，但仅在 ML 阶段（Delta 6 +/- 1 次突发 min(-1)；P < 0.01）在恢复的最后 5 分钟期间保持升高。我们的结果表明，年轻健康女性在月经周期的 EF 和 ML 阶段，在休息或精神压力期间的 MSNA、MAP 和 HR 反应没有不同。然而，与 EF 阶段相比，ML 阶段从精神压力恢复过程中 MSNA 的激活时间延长。
The influence of the menstrual cycle on resting muscle sympathetic nerve activity (MSNA) remains controversial, and the effect of the menstrual cycle on MSNA responses to mental stress is unknown. We examined MSNA, mean arterial pressure (MAP), and heart rate (HR) responses to mental stress (via mental arithmetic) in 11 healthy females during the early follicular (EF) and mid-luteal (ML) phases of the menstrual cycle. The menstrual cycle did not alter resting MSNA (EF, 13 +/- 3 bursts min(-1) versus ML, 13 +/- 2 bursts min(-1)), MAP (EF, 79 +/- 3 mmHg versus ML, 81 +/- 2 mmHg) and HR (EF, 66 +/- 3 beats min(-1) versus ML, 64 +/- 2 beats min(-1)). 5 min of mental stress increased MSNA, MAP and HR during both the EF (Delta 4 +/- 2 bursts min(-1), Delta 12 +/- 2 mmHg, Delta 18 +/- 2 beats min(-1); P < 0.05) and ML (Delta 4 +/- 2 bursts min(-1), Delta 13 +/- 3 mmHg and Delta 20 +/- 2 beats min(-1); P < 0.05) phases. These responses were not different between phases. In contrast, MSNA responses were different between phases during the 10 min recovery from mental stress. MSNA remained elevated during the initial 5 min of recovery in both the EF (Delta 6 +/- 1 bursts min(-1); P < 0.01) and ML (Delta 7 +/- 1 bursts min(-1); P < 0.01) phases, but only remained elevated during the ML phase (Delta 6 +/- 1 bursts min(-1); P < 0.01) during the final 5 min of recovery. Our results demonstrate that MSNA, MAP and HR responses at rest or during mental stress are not different during the EF and ML phases of the menstrual cycle in young, healthy females. However, MSNA activation during recovery from mental stress is prolonged during the ML phase compared to the EF phase.