Platelet concentrate injection improves Achilles tendon repair in rats
Platelet concentrate injection improves Achilles tendon repair in rats
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DOI：
10.1080/00016470410001708190
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发表时间：
2004-02-01
期刊：
影响因子：
--
通讯作者：
Virchenko, O
中科院分区：
文献类型：
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作者：
Aspenberg, P;Virchenko, O
背景血小板激活时释放生长因子的鸡尾酒，其中一些被认为是启动和刺激repair.Experiment和调查结果我们研究了血小板浓缩注射是否会改善跟腱修复在一个既定的大鼠模型。横断跟腱并取出3 mm节段。6小时后，将浓缩血小板经皮注射到血肿中。这在1周后增加了肌腱骨痂强度和刚度约30%，并在注射后持续长达3周。此时，机械测试表明材料特性的改善，即，肌腱愈伤组织更成熟。这一点通过盲法组织学评分得到证实。解释浓缩血小板可能被证明对跟腱断裂的治疗有用。
Background Blood platelets release a cocktail of growth factors when activated, some of which are thought to initiate and stimulate repair.Experiment and findings We studied whether a platelet concentrate injection would improve Achilles tendon repair in an established rat model. The Achilles tendon was transected and a 3 mm segment removed. After 6h, a platelet concentrate was injected percutaneously into the hematoma. This increased tendon callus strength and stiffness by about 30% after 1 week, which persisted for as long as 3 weeks after the injection. At this time, the mechanical testing indicated an improvement in material characteristics-i.e., greater maturation of the tendon callus. This was confirmed by blinded histological scoring.Interpretation Platelet concentrate may prove useful for the treatment of Achilles tendon ruptures.