Initial results from a multi-center population-based cluster randomized trial of esophageal and gastric cancer screening in China.
Initial results from a multi-center population-based cluster randomized trial of esophageal and gastric cancer screening in China.
复制标题
中国食管癌和胃癌筛查多中心人群整群随机试验的初步结果
DOI：
10.1186/s12876-020-01517-3
复制
发表时间：
2020-11-24
影响因子：
2.4
通讯作者：
He J
中科院分区：
文献类型：
--
作者：
Zeng H;Sun K;Cao M;Zheng R;Sun X;Liu S;Zhang Z;Liu Y;Guo G;Song G;Zhu Y;Wu X;Song B;Liao X;Chen Y;Song M;Giovannucci E;Zhuang G;Wei W;Chen W;He J
背景我们在国内首次开展了食管癌和胃癌内镜筛查的多中心随机整群试验。这项研究的目的是报告基线筛选结果在此trial.MethodsWe招募了345个合格的集群从7个筛选中心。在干预组中，来自高风险地区的参与者通过内窥镜检查进行筛查;在非高风险地区，使用问卷确定高风险个体并建议进行内窥镜检查。可疑病变行食管卢戈氏碘染色及胃靛蓝胭脂染色。本研究的主要结果是检出率（进行内镜筛查的个体中阳性病例的比例）和早期检出率（所有阳性病例中0/I期阳性病例的比例）。食管和胃的检出率分别为0.7%和0.8%。与非高发区相比，高发区的检出率更高，无论是食管（0.9% vs. 0.1%）还是胃（0.9% vs. 0.3%）。同样的差异被发现早期检测率（食管：92.9%对53.3%;胃：81.5%对33.3%）。结论食管和胃的诊断率在高风险地区高于非高风险地区，即使在非高风险地区，只有高风险的个人进行了筛选。我们的研究可能为评估和提高中国上消化道内镜筛查的有效性提供重要线索。试验注册：中国临床试验注册中心方案注册系统，ChiCTR-EOR-16008577。2016年6月01日注册-Retroplastics registered，http://www.chictr.org.cn/showprojen.aspx? proj=14372
BackgroundWe initiated the first multi-center cluster randomized trial of endoscopic screening for esophageal cancer and gastric cancer in China. The objective of the study was to report the baseline screening findings in this trial.MethodsWe recruited a total of 345 eligible clusters from seven screening centers. In the intervention group, participants from high-risk areas were screened by endoscopy; in non-high-risk areas, high-risk individuals were identified using a questionnaire and advised for endoscopy. Lugol’s iodine staining in esophagus and indigo carmine dye in stomach were performed to aid in the diagnosis of suspicious lesions. The primary outcomes of this study were the detection rate (proportion of positive cases among individuals who underwent endoscopic screening) and early detection rate (the proportion of positive cases with stage 0/I among all positive cases).ResultsA total of 149,956 eligible subjects were included. The detection rate was 0.7% in esophagus and 0.8% in stomach, respectively. Compared with non-high-risk areas, the detection rates in high-risk areas were higher, both in esophagus (0.9% vs. 0.1%) and in stomach (0.9% vs. 0.3%). The same difference was found for early-detection rate (esophagus: 92.9% vs. 53.3%; stomach: 81.5% vs. 33.3%).ConclusionsThe diagnostic yield of both esophagus and stomach were higher in high-risk areas than in non-high-risk areas, even though in non-high-risk areas, only high-risk individuals were screened. Our study may provide important clues for evaluating and improving the effectiveness of upper-endoscopic screening in China.Trial registration: Protocol Registration System in Chinese Clinical Trial Registry, ChiCTR-EOR-16008577. Registered 01 June 2016-Retrospectively registered, http://www.chictr.org.cn/showprojen.aspx?proj=14372
登录
查看更多内容
影响因子：
29.4
作者：
Jun, Jae Kwan;Choi, Kui Son;Lee, Dukhyoung
通讯作者：
Lee, Dukhyoung
中国食管癌强化内镜筛查的有效性：基于社区的研究
影响因子：
5
作者：
Liu, Mengfei;He, Zhonghu;Ke, Yang
通讯作者：
Ke, Yang
影响因子：
5.7
作者：
Guan CT;Song GH;Li BY;Gong YW;Hao CQ;Xue LY;Chen WQ;Wei WQ
通讯作者：
Wei WQ
DOI：
10.21147/j.issn.1000-9604.2017.04.02
发表时间：
2017-08
期刊：
Chinese journal of cancer research = Chung-kuo yen cheng yen chiu
影响因子：
--
作者：
Chen W;Zeng H;Chen R;Xia R;Yang Z;Xia C;Zheng R;Wei W;Zhuang G;Yu X;He J
通讯作者：
He J
影响因子：
45.3
作者：
Wei, Wen-Qiang;Chen, Zhi-Feng;Qiao, You-Lin
通讯作者：
Qiao, You-Lin