Involvement of spinal monocyte chemoattractant protein-1 (MCP-1) in cancer-induced bone pain in rats
Involvement of spinal monocyte chemoattractant protein-1 (MCP-1) in cancer-induced bone pain in rats
复制标题
脊髓单核细胞趋化蛋白-1 (MCP-1) 参与癌症引起的大鼠骨痛
DOI：
10.1016/j.neulet.2012.04.026
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发表时间：
2012-05-23
影响因子：
2.5
通讯作者：
Ji, Fu-Hai
中科院分区：
文献类型：
--
作者：
Hu, Ji-Hua;Zheng, Xiao-Yan;Ji, Fu-Hai
在这项研究中，我们研究了参与的趋化因子单核细胞趋化蛋白-1（MCP-1）在大鼠模型的癌症引起的骨痛（CIBP）的脊髓。在这个模型中。通过将步行者256细胞髓内注射到大鼠胫骨中来建立CIBP。我们观察到CIBP大鼠脊髓中MCP-1及其受体CCR 2的表达水平显著增加。此外，鞘内施用抗MCP-1中和抗体减弱了CIBP大鼠中建立的机械性异常性疼痛。同样地，鞘内注射外源性重组MCP-1诱导了幼稚大鼠显著的机械异常性疼痛。这些结果表明，脊髓MCP-1和CCR 2表达的增加参与了骨癌大鼠相关的机械异常性疼痛的发展。(c)2012爱思唯尔爱尔兰有限公司保留所有权利。
In this study, we examined the involvement of chemokine monocyte chemoattractant protein-1 (MCP-1) in the spinal cord of a rat model of cancer-induced bone pain (CIBP). In this model. CIBP was established by an intramedullary injection of Walker 256 cells into the tibia of rats. We observed a significant increase in expression levels of MCP-1 and its receptor CCR2 in the spinal cord of CIBP rats. Furthermore, the intrathecal administration of an anti-MCP-1 neutralizing antibody attenuated the mechanical allodynia established in CIBP rats. Likewise, an intrathecal injection of exogenous recombinant MCP-1 induced a striking mechanical allodynia in naive rats. These results suggest that increases in spinal MCP-1 and CCR2 expression are involved in the development of mechanical allodynia associated with bone cancer rats. (c) 2012 Elsevier Ireland Ltd. All rights reserved.