Prevalence of major and minor depression in elderly persons with mild cognitive impairment - MADRS factor analysis
Prevalence of major and minor depression in elderly persons with mild cognitive impairment - MADRS factor analysis
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DOI：
10.1002/gps.1235
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发表时间：
2004-12-01
影响因子：
4
通讯作者：
Barcikowska, M
中科院分区：
文献类型：
--
作者：
Gabryelewicz, T;Styczynska, M;Barcikowska, M
目的 检测轻度认知障碍（MCI）老年人样本中抑郁综合征和症状的患病率，并分析蒙哥马利-阿斯伯格抑郁量表（MADRS）项目评分。 方法 研究对象为连续102例门诊轻度认知障碍患者。所有受试者均由经验丰富的精神科医生进行评估并应用 MADRS。根据 DSM-IV 标准定义重度和轻度抑郁发作。采用因子分析法分析基线 MADRS 项目评分。 结果 根据抑郁症状分布和严重程度评分基础，出现三个患者组：重度抑郁症占 19.6%（n = 20），轻度抑郁症占 26.5%（n = 27），很少抑郁症状占 53.9%（n = 55）。使用 Varimax 旋转因子分析确定了三个可解释的 MADRS 因素：第一个由明显和报告的悲伤、感觉无力、悲观想法组成，第二个由内心紧张、睡眠减少、食欲下降、自杀想法组成，第三个由注意力集中困难和疲倦组成。结论得出的结论是，重度抑郁症和轻度抑郁症在 MCI 中都很常见。三个 MADRS 因素被确定并标记为快感缺乏-悲观主义、焦虑-植物性和认知-抑制。版权所有 (C) 2004 John Wiley Sons, Ltd.
Objective The aim of the study was to detect the prevalence of depressive syndromes and symptoms in the sample of elderly persons with Mild Cognitive Impairment (MCI), and to analyse Montgomery-Asberg Depression Rating (MADRS) item scores.Method The subjects of the study were 102 consecutive out-patients with MCI. All subjects were assessed by an experienced psychiatrist and MADRS was applied. Major and minor depressive episodes were defined according to DSM-IV criteria. Factor analysis was used to analyse baseline MADRS item scores.Results Three patient groups emerged according to the depressive symptoms distribution and severity scores basis: those with major depression constituted 19.6% (n = 20), with minor depression 26.5% (n = 27), and with very few depressive symptoms 53.9% (n = 55). Three interpretable MADRS factors were identified, using the factor analysis with Varimax rotation: the first consisting of apparent and reported sadness, inability to feel, pessimistic thoughts, the second consisting of inner tension, reduced sleep, reduced appetite, suicidal thoughts, and the third with concentration difficulties and lassitude.Conclusions It was concluded that both major and minor depression is common in MCI. Three MADRS factors were identified and labelled as anhedonia-pessimism, anxiety-vegetative, and cognitive-inhibition. Copyright (C) 2004 John Wiley Sons, Ltd.