Essential and nonessential fatty acid oxidation in mice bearing Ehrlich ascites carcinoma.
Essential and nonessential fatty acid oxidation in mice bearing Ehrlich ascites carcinoma.
复制标题
患有艾利希腹水癌的小鼠的必需和非必需脂肪酸氧化。
作者：
Ookhtens,M;Baker,N
We tested the hypothesis that mobilized (essential) free fatty acids (FFA) are spared from oxidation in cancer‐bearing animals. We injected tracers [1‐14C]linoleate, [1‐14C] palmitate and NaH14CO3intravenously as single rapid doses in separate groups of mice bearing Ehrlich ascites tumor (EAT) and controls, and measured breath14CO2. The data from NaH14CO3injections were used to develop kinetic, compartmental models of the HCO3−‐CO2systems. These models were integrated with our earlier model of plasma FFA turnover for control and EAT‐bearing mice. The integrated multicompartmental models were then fitted to breath14CO2data from mice injected with tracer FFA to compute the rates of FFA oxidation. FFA were not spared from an oxidative fate in our cancer‐bearing vs normal animals; moreover, essential FFA were not preferentially spared from oxidation compared to nonessential FFA in the cancer‐bearing mice.
