Cycad neurotoxins, consumption of flying foxes, and ALS-PDC disease in Guam
Cycad neurotoxins, consumption of flying foxes, and ALS-PDC disease in Guam
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DOI：
10.1212/wnl.58.6.956
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发表时间：
2002-03-26
期刊：
影响因子：
9.9
通讯作者：
Sacks, OW
中科院分区：
文献类型：
--
作者：
Cox, PA;Sacks, OW
关岛的查莫罗人患有一种复杂的神经退行性疾病（现在称为ALS-PDC），与ALS，AD和PD相似，其发病率远远高于世界各地的其他人群。查莫罗消费狐蝠可能产生足够高的累积剂量的植物神经毒素，导致ALS-PDC神经病理学，因为狐蝠饲料神经毒性苏铁种子。
The Chamorro people of Guam have been afflicted with a complex of neurodegenerative diseases (now known as ALS-PDC) with similarities to ALS, AD, and PD at a far higher rate than other populations throughout the world. Chamorro consumption of flying foxes may have generated sufficiently high cumulative doses of plant neurotoxins to result in ALS-PDC neuropathologies, since the flying foxes forage on neurotoxic cycad seeds.