Hitchhiking mapping:: A population-based fine-mapping strategy for adaptive mutations in Drosophila melanogaster
Hitchhiking mapping:: A population-based fine-mapping strategy for adaptive mutations in Drosophila melanogaster
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DOI：
10.1073/pnas.202336899
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发表时间：
2002-10-01
影响因子：
11.1
通讯作者：
Schlötterer, C
中科院分区：
文献类型：
--
作者：
Harr, B;Kauer, M;Schlötterer, C
The identification of genes contributing to the adaptation of local populations is of great biological interest. In an attempt to characterize functionally important differences among African and non-African Drosophila melanogaster populations, we surveyed neutral microsatellite variation in an 850-kb genomic sequence. Three genomic regions were identified that putatively bear an adaptive mutation associated with the habitat expansion of D. melanogaster. A further inspection of two regions by sequence analysis of multiple fragments confirmed the presence of a recent beneficial mutation in the non-African populations. Our study suggests that hitchhiking mapping is a universal approach for the identification of ecologically important mutations.
