An antioxidant system required for host protection against gut infection in Drosophila
An antioxidant system required for host protection against gut infection in Drosophila
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DOI：
10.1016/j.devcel.2004.11.007
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发表时间：
2005-01-01
影响因子：
11.8
通讯作者：
Lee, WJ
中科院分区：
文献类型：
--
作者：
Ha, EM;Oh, CT;Lee, WJ
适用于所有生物体的一个基本问题是屏障上皮细胞如何有效地管理与微生物的持续接触。在这里，我们表明，在果蝇中，细胞外免疫调节的过氧化氢酶(IRC)介导了胃肠道中宿主-微生物相互作用所需的关键宿主防御系统。引人注目的是，IRC表达严重减少的成年果蝇，即使在简单地摄入了受微生物污染的食物后，也表现出高死亡率。然而，尽管核因子-kappaB途径在诱导抗微生物反应中起着核心作用，但核因子-kappaB途径突变的果蝇对这种感染是完全抵抗的。这些结果表明，IRC氧化还原平衡的动态平衡是影响宿主在胃肠道中持续的宿主-微生物相互作用的最关键因素之一。
A fundamental question that applies to all organisms is how barrier epithelia efficiently manage continuous contact with microorganisms. Here, we show that in Drosophila an extracellular immune-regulated catalase (IRC) mediates a key host defense system that is needed during host-microbe interaction in the gastrointestinal tract. Strikingly, adult flies with severely reduced IRC expression show high mortality rates even after simple ingestion of microbe-contaminated foods. However, despite the central role that the NF-kappaB pathway plays in eliciting antimicrobial responses, NF-kappaB pathway mutant flies are totally resistant to such infections. These results imply that homeostasis of redox balance by IRC is one of the most critical factors affecting host survival during continuous host-microbe interaction in the gastrointestinal tract.