High-dose ascorbic acid increases intercourse frequency and improves mood: A randomized controlled clinical trial
High-dose ascorbic acid increases intercourse frequency and improves mood: A randomized controlled clinical trial
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DOI：
10.1016/s0006-3223(02)01329-x
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发表时间：
2002-08-15
影响因子：
10.6
通讯作者：
Brody, S
中科院分区：
文献类型：
--
作者：
Brody, S
背景：抗坏血酸(AA)调节儿茶酚胺能活性，降低应激反应，接近焦虑和催乳素释放，改善血管功能，增加催产素释放。方法：在这项随机、双盲、安慰剂对照的14天试验中，AA缓释剂(42名健康青年；西替比片3000 mg/天)和安慰剂(39名健康青年)在日常日记中记录了阴茎-阴道性交(FSI)、非交性伴性行为和手淫，并在试验前后完成了Beck抑郁量表。结果：AA组报告FSI频率增加(但假设不是其他性行为)，这种影响在没有与性伴侣同居的受试者和女性中最为显著。AA组而不是安慰剂组也经历了Beck抑郁评分的下降。结论：AA似乎增加了FSI，对非同居者的不同益处表明，中枢激活或去抑制，而不是外围机制可能起作用。(C)2002年生物精神病学学会。
Background: Ascorbic acid (AA) modulates catecholaminergic activity, decreases stress reactivity, approach anxiety and prolactin release, improves vascular function, and increases oxytocin release. These processes are relevant to sexual behavior and mood.Methods: In this randomized double-blind, placebo-controlled 14 day trial of sustained-release AA (42 healthy young adults; 3000 mg/day Cetebe) and placebo (39 healthy young adults), subjects with partners recorded penile-vaginal intercourse (FSI), noncoital partner sex, and masturbation in daily diaries, and also completed the Beck Depression Inventory before and after the trial.Results: The AA group reported greater FSI (but, as hypothesized, not other sexual behavior) frequency, an effect most prominent in subjects not cohabiting with their sexual partner, and in women. The AA but not placebo group also experienced a decrease in Beck Depression scores.Conclusions: AA appears to increase FSI, and the differential benefit to noncohabitants suggests that a central activation or disinhibition, rather than peripheral mechanism may be responsible. (C) 2002 Society of Biological Psychiatry.