ACTIVE MUSCLE VASODILATATION PRODUCED BY STIMULATION OF THE BRAIN STEM - ITS SIGNIFICANCE IN THE DEFENCE REACTION
ACTIVE MUSCLE VASODILATATION PRODUCED BY STIMULATION OF THE BRAIN STEM - ITS SIGNIFICANCE IN THE DEFENCE REACTION
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DOI：
10.1113/jphysiol.1960.sp006593
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发表时间：
1960-01-01
影响因子：
5.5
通讯作者：
ZBROZYNA, A
中科院分区：
文献类型：
--
作者：
ABRAHAMS, VC;HILTON, SM;ZBROZYNA, A
在麻醉猫的区域已被映射在下丘脑，中脑被盖和中央灰质，从主动阿托品敏感的肌肉血管扩张引起的电刺激。这三个脑干区域不仅仅是肌肉的“血管扩张”区域，血管扩张还伴随着其他自主效应，包括动脉血压升高、皮肤和肠道血管收缩、瞳孔扩张、瞬膜收缩和毛发勃起，以及呼吸变化和下颌、四肢和尾巴的运动。通过植入电极刺激有意识的猫脑干的所有三个区域，产生协调的防御反应。结论：肌肉血管舒张是综合反应的一个组成部分。另外一个限制性区域位于大脑脚的背侧，刺激该区域可使麻醉猫产生主动肌肉血管舒张，而在清醒猫中，则产生单一或无组织的运动。大脑脚背侧区域的病变取消了对下丘脑刺激的血管舒张反应。可以得出结论，肌肉血管舒张的途径在这个脚区域运行。在高去脑猫，皮肤刺激反射性地产生防御反应的许多功能，包括积极的肌肉血管舒张。它的结论是，下丘脑，中脑被盖和中央灰质的反射中心的协调自主和行为反应，包括防御反应的功能区域。
In anesthetized cats regions have been mapped in the hypothalamus, mesencephalic tegmentum and central grey matter from which active atropine-sensitive muscle vasodilatation is elicited on electrical stimulation. These three brain-stem regions are not merely "vasodilator" areas for the muscle vasodilatation is accompanied by other autonomic effects including a rise in arterial blood pressure, vasoconstriction in skin and intestine, pupil dilatation, retraction of the nictitating membranes and pilo-erection, by respiratory changes and movements of the jaw, limbs and tail. Stimulation of all three brain-stem regions in the conscious cat through implanted electrodes produces co-ordinated defence reactions. It is concluded that the muscle vasodilatation is one component of the integrated response. An additional, restricted region has been located just dorsal to the cerebral peduncles, stimulation of which produces active muscle vasodilatation in anesthetized cats, and, in conscious cats, single or unorganized movements. Lesions in the region dorsal to the cerebral peduncles abolish the vasodilator response to hypothalamic stimulation. It is concluded that the pathway for muscle vasodilatation runs in this peduncular region. In the high decerebrate cat, cutaneous stimulation reflexly produces many of the features of the defence reaction, including active muscle vasodilatation. It is concluded that the regions of the hypothalamus, mesencephalic tegmentum and central grey matter function as reflex centers for the co-ordinated autonomic and behavioral responses that comprise the defence reaction.