Modulation of striatal dopamine D1 binding by cognitive processing
Modulation of striatal dopamine D1 binding by cognitive processing
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DOI：
10.1016/j.neuroimage.2009.06.030
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发表时间：
2009-11-01
期刊：
影响因子：
5.7
通讯作者：
Backman, Lars
中科院分区：
文献类型：
--
作者：
Karlsson, Sari;Nyberg, Lars;Backman, Lars
有强有力的证据表明多巴胺（DA）与高阶认知功能有关，但D1受体的结合是否可以通过认知活动来改变仍然存在争议。我们检测了20名年轻人（22-30岁）和20名老年人（65-75岁）的纹状体D1结合电位（BP），他们接受了两次[C-11] SCH 23390 PET测量，一次在休息时，一次在执行涉及抑制功能的认知任务时。与休息时相比，年轻人在认知活动中表现出明显的感觉运动、边缘和联想纹状体的任务相关血压降低。老年人在纹状体亚区没有可靠的血压降低。这些发现表明，年轻人的认知活动可以改变D1受体的结合，同时也为人类衰老不仅与DA受体密度降低有关，而且与DA系统的可修饰性改变有关的概念提供了新的证据。(C) 2009爱思唯尔公司版权所有。
There is strong evidence that dopamine (DA) is implicated in higher-order cognitive functioning, but it remains controversial whether D1 receptor binding can be modified by cognitive activity. We examined striatal D1 binding potential (BP) in 20 younger (22-30 years) and 20 older (65-75 years) persons who underwent two [C-11] SCH 23390 PET measurements, one while resting and one while performing a cognitive task taxing inhibitory functioning. The younger persons showed significant task-related BP reductions in sensorimotor, limbic, and associative striatum during cognitive activity compared to rest. Older persons showed no reliable BP reductions in any striatal subregion. These findings demonstrate that D1 receptor binding can be modified by cognitive activity in younger persons, but also provide novel evidence for the notion that human aging is associated not only with lower DA receptor density but also with altered modifiability of the DA system. (C) 2009 Elsevier Inc. All rights reserved.