Synthesis and Biological Evaluation of Some [1,2,4]Triazolo[4,3-a]quinoxaline Derivatives as Novel Anticonvulsant Agents.
Synthesis and Biological Evaluation of Some [1,2,4]Triazolo[4,3-a]quinoxaline Derivatives as Novel Anticonvulsant Agents.
复制标题
DOI：
10.1155/2013/587054
复制
发表时间：
2013
期刊：
影响因子：
--
通讯作者：
El-Gamal K
中科院分区：
文献类型：
--
作者：
Alswah M;Ghiaty A;El-Morsy A;El-Gamal K
以2-（[1,2,4]三唑[4,3-a]喹诺啉-4-基硫代）乙酸肼（10）为前体，合成了具有抗惊厥作用的新型喹诺啉衍生物。新合成的化合物已通过IR， 1H NMR和质谱数据进行了表征，然后进行了元素分析。以美曲唑诱发惊厥模型和苯巴比妥钠为标准，对合成的11种化合物进行抗惊厥评价。其中2个化合物（14和15b）的抗惊厥活性最好。
2-([1,2,4]Triazolo[4,3-a]quinoxalin-4-ylthio)acetic acid hydrazide (10) was used as a precursor for the syntheses of novel quinoxaline derivatives with potential anticonvulsant properties. The newly synthesized compounds have been characterized by IR, 1H NMR, and mass spectral data followed by elemental analysis. The anticonvulsant evaluation was carried out for eleven of the synthesized compounds using metrazol induced convulsions model and phenobarbitone sodium as a standard. Among this set of tested compounds, two of them (14, and 15b) showed the best anticonvulsant activities.