Affect of spleen and snake venom phosphodiesterases on nucleotides containing nucleosides in the syn conformation.
Affect of spleen and snake venom phosphodiesterases on nucleotides containing nucleosides in the syn conformation.
复制标题
脾和蛇毒磷酸二酯酶对含有顺式构象核苷的核苷酸的影响。
DOI：
10.1016/0006-291x(76)91155-4
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发表时间：
1976
影响因子：
3.1
通讯作者：
F. Hruška
中科院分区：
文献类型：
--
作者：
K. K. Ogilvie;F. Hruška
含有6-甲基脱氧尿苷和肌苷的二核苷酸已被制备并经受脾和蛇毒磷酸二酯酶。脾酶降解所有测试的核苷酸，而蛇毒对3′-末端位置具有6-甲基脱氧尿苷的核苷酸的降解非常少。这清楚地表明，蛇毒不能识别这种同构型的核苷单元。
Dinucleotides containing 6-methyldeoxyuridine and inosine have been prepared and subjected to spleen and snake venom phosphodiesterases. Spleen enzyme degrades all nucleotides tested while snake venom causes very little degradation of nucleotides having 6-methyldeoxyuridine in the 3′-terminal position. The clear implication is that snake venom will not recognize nucleoside units in thesynconformation.