Global analysis of transcript and protein levels across the Plasmodium falciparum life cycle
Global analysis of transcript and protein levels across the Plasmodium falciparum life cycle
复制标题
DOI：
10.1101/gr.2523904
复制
发表时间：
2004-11-01
期刊：
影响因子：
7
通讯作者：
Winzeler, EA
中科院分区：
文献类型：
--
作者：
Le Roch, KG;Johnson, JR;Winzeler, EA
为了研究转录后调控在疟疾寄生虫恶性疟原虫蛋白质表达调控中的作用，我们比较了寄生虫生命周期7个不同阶段的mRNA转录和蛋白质丰度水平。在这些阶段，mRNA和蛋白质丰度之间存在中等程度的正相关关系;最常见的差异是mRNA和蛋白质积累之间的延迟。潜在的转录后调节基因被确定，并观察到功能相关基因家族共享类似的mRNA和蛋白质积累模式。
To investigate the role of post-transcriptional controls in the regulation of protein expression for the malaria parasite, Plasmodium falciparum, we have compared mRNA transcript and protein abundance levels for seven different stages of the parasite life cycle. A moderately high positive relationship between mRNA and protein abundance was observed for these stages; the most common discrepancy was a delay between mRNA and protein accumulation. Potentially post-transcriptionally regulated genes are identified, and families of functionally related genes were observed to share similar patterns of mRNA and protein accumulation.