EFFECT OF COCARBOXYLASE IN DOGS SUBJECTED TO EXPERIMENTAL SEPTIC SHOCK
EFFECT OF COCARBOXYLASE IN DOGS SUBJECTED TO EXPERIMENTAL SEPTIC SHOCK
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DOI：
10.1097/00003246-198910000-00014
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发表时间：
1989-10-01
影响因子：
8.8
通讯作者：
KAPUSNICK, RA
中科院分区：
文献类型：
--
作者：
LINDENBAUM, GA;LARRIEU, AJ;KAPUSNICK, RA
我们研究了辅羧化酶治疗对内毒素休克犬血流动力学参数和代谢功能的影响。辅羧化酶抑制代谢功能的恶化，如通过改善pH和碱过剩以及维持正常的氧消耗所反映的。平均动脉压和心脏指数也有显著改善。辅羧化酶是线粒体丙酮酸脱氢酶的主要辅酶，并可能通过该复合物发挥其有益作用。
We examined the effects of cocarboxylase treatment on both the hemodynamic variables and metabolic function during endotoxic shock in dogs. Cocarboxylase inhibited deterioration in metabolic function as reflected by improved pH and base excess as well as maintenance of normal oxygen consumption. Significant improvements in mean arterial pressure and cardiac index were also seen. Cocarboxylase is a major coenzyme of mitochondrial pyruvate dehydrogenase and may exert its beneficial effects via this complex.