Lipid rafts, fluid/fluid phase separation, and their relevance to plasma membrane structure and function.
Lipid rafts, fluid/fluid phase separation, and their relevance to plasma membrane structure and function.
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DOI：
10.1016/j.semcdb.2007.07.010
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发表时间：
2007-10
影响因子：
7.3
通讯作者：
P. Sengupta;B. Baird;D. Holowka
中科院分区：
文献类型：
--
作者：
P. Sengupta;B. Baird;D. Holowka
新颖的生物物理方法与建模和新的生化数据相结合，有助于补充脂筏场，并有助于生成质膜组织的精细模型。在这篇综述中，我们总结了先前文献中的新信息，为活细胞质膜中脂质和蛋白质的空间组织和动力学提供新的见解。最近对质膜囊泡中液体有序相和液体无序相的大规模分离的发现证明了质膜蛋白和脂质的复杂环境中的这种能力。根据这一新信息讨论了膜异质性和重组在免疫细胞激活中的作用。
Novel biophysical approaches combined with modeling and new biochemical data have helped to recharge the lipid raft field and have contributed to the generation of a refined model of plasma membrane organization. In this review, we summarize new information in the context of previous literature to provide new insights into the spatial organization and dynamics of lipids and proteins in the plasma membrane of live cells. Recent findings of large-scale separation of liquid-ordered and liquid-disordered phases in plasma membrane vesicles demonstrate this capacity within the complex milieu of plasma membrane proteins and lipids. Roles for membrane heterogeneity and reorganization in immune cell activation are discussed in light of this new information.