Prognostication Value of Descending Corticospinal Tract DWI Signal in Neonatal Cerebral Sinovenous Thrombosis
Prognostication Value of Descending Corticospinal Tract DWI Signal in Neonatal Cerebral Sinovenous Thrombosis
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DOI：
10.1016/j.pediatrneurol.2016.02.004
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发表时间：
2016-06-01
影响因子：
3.8
通讯作者：
Dlamini, Nomazulu
中科院分区：
文献类型：
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作者：
Kaseka, Matsanga Leyila;Moharir, Mahendranath;Dlamini, Nomazulu
背景：下行皮质脊髓束扩散加权磁共振成像（MRI）信号可预测新生儿和儿童动脉缺血性卒中的不良运动结局。然而，在脑窦静脉血栓形成的情况下，尚未记录皮质脊髓束下行扩散加权 MRI 信号，其作用尚不清楚。目的：我们描述了一名患有脑窦静脉血栓、广泛弥散受限、双侧皮质脊髓下降束、脑部 MRI 弥散加权 MRI 信号的新生儿。我们讨论这些发现对静脉缺血的潜在机制和影响。结论：在脑窦静脉血栓形成中观察到的皮质脊髓束下行扩散加权 MRI 信号的预后价值与在动脉缺血性卒中中观察到的不同。因此，在使用皮质脊髓下行扩散加权 MRI 信号来预测脑静脉血栓形成儿童的预后时应谨慎。
BACKGROUND: Descending corticospinal tract diffusion-weighted magnetic resonance imaging (MRI) signal is predictive of poor motor outcome in neonatal and childhood arterial ischemic stroke. However, descending corticospinal tract diffusion-weighted MRI signal has not been documented in the setting of cerebral sinovenous thrombosis, and its role is not understood. OBJECTIVE: We describe a neonate with cerebral sinovenous thrombosis, extensive diffusion restriction, and bilateral descending corticospinal tract,diffusion-weighted MRI signal on MRI of the brain. We discuss the underlying mechanisms and implications of these findings in venous ischemia. CONCLUSION: The prognostic value of descending corticospinal tract diffusion-weighted MRI signal differs when observed in cerebral sinovenous thrombosis from when observed in arterial ischemic stroke. Consequently, caution should be exercised in using descending corticospinal tract diffusion-weighted MRI signal to predict outcome in children with cerebral sinovenous thrombosis.