Adrenergic regulation of capsaicin-sensitive neurons in dental pulp
Adrenergic regulation of capsaicin-sensitive neurons in dental pulp
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DOI：
10.1097/00004770-200306000-00004
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发表时间：
2003-06-01
影响因子：
4.2
通讯作者：
Bowles, WR
中科院分区：
文献类型：
--
作者：
Hargreaves, KM;Jackson, DL;Bowles, WR
α肾上腺素能激动剂（例如血管收缩剂）是牙科中最常用的药物类别之一。虽然肾上腺素能激动剂具有强有力的血管效应，但最近的研究表明，辣椒素敏感的伤害感受器可能表达肾上腺素受体，这表明这些药物可能直接调节外周组织中一类重要的疼痛信号神经元的功能。在这项研究中，我们测试的假设，肾上腺素能受体激动剂抑制激活的辣椒素敏感性纤维支配牙髓的周边终端。肾上腺素或可乐定预处理显著抑制辣椒素诱导的牛牙髓降钙素基因相关肽的释放。这些研究表明，肾上腺素能激动剂可能通过直接抑制辣椒素敏感性伤害感受器来部分减轻术后疼痛。这一发现可能导致选择性，外周作用，肾上腺素能镇痛药的发展。此外，由于神经肽释放改变血流，这些药物的血管效应可能是由血管收缩和外周神经肽释放的抑制引起的。
Alpha adrenergic agonists (e.g. vasoconstrictors) represent one of the most commonly used drug classes in dentistry. Although adrenergic agonists have potent vascular effects, recent studies suggest that capsaicin-sensitive nociceptors may express adrenoceptors, suggesting that these drugs may directly modulate the function of an important class of pain-signaling neurons in peripheral tissues. In this study, we tested the hypothesis that adrenergic agonists inhibit activation of peripheral terminals of capsaicin-sensitive fibers innervating dental pulp. Pretreatment with epinephrine or clonidine significantly inhibited capsaicin-evoked release of immunoreactive calcitonin gene-related peptide from superfused bovine dental pulp. These studies suggest that adrenergic agonists may reduce postoperative pain in part via a direct inhibition of capsaicin-sensitive nociceptors. This finding may lead to the development of selective, peripherally acting, adrenergic analgesics. Moreover, because neuropeptide release alters blood flow, it is possible that the vascular effects of these drugs are caused by both vasoconstriction and inhibition of peripheral neuropeptide release.