Distribution of Retinal Layer Atrophy in Patients With Parkinson Disease and Association With Disease Severity and Duration
Distribution of Retinal Layer Atrophy in Patients With Parkinson Disease and Association With Disease Severity and Duration
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DOI：
10.1016/j.ajo.2013.09.028
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发表时间：
2014-02-01
影响因子：
4.2
通讯作者：
Pablo, Luis E.
中科院分区：
文献类型：
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作者：
Garcia-Martin, Elena;Larrosa, Jose M.;Pablo, Luis E.
目得：评价帕金森病患者黄斑旁区视网膜10层的厚度，使用一种新的分割技术的光学相干断层扫描（OCT），以检查是否特定层的厚度预测神经变性或帕金森病severity.DESIGN：观察性前瞻性研究方法：帕金森病患者（n = 129）和年龄匹配的健康受试者（n = 129）被纳入。Spectralis OCT系统使用新的分割应用程序原型，在视网膜旁扫描中自动分割所有视网膜层。计算每层的平均厚度，并在帕金森病患者和健康受试者之间，以及在疾病持续时间小于或至少10年的帕金森病患者之间进行比较。进行相关性分析以评估视网膜层厚度、疾病持续时间和帕金森病严重程度之间的关联。结果：帕金森病患者视网膜神经纤维层、神经节细胞层、内丛状层、外丛状层厚度均较健康人明显减少，内核层厚度较健康人明显增加（P
PURPOSE: To evaluate the thickness of the 10 retinal layers in the paramacular area-of Parkinson disease patients using a new segmentation technology of optical coherence tomography (OCT) to examine whether the thickness of specific layers predicts neurodegeneration or Parkinson disease severity.DESIGN: Observational prospective study.METHODS: Parkinson disease patients (n = 129) and age-matched healthy subjects (n = 129) were enrolled. The Spectralis OCT system was used to automatically segment all retinal layers in a parafoveal scan using the new segmentation application prototype. Mean thickness of each layer was calculated and compared between Parkinson disease patients and healthy subjects, and between Parkinson disease patients with disease durations of less than or at least 10 years. A correlation analysis was performed to evaluate the association between retinal layer thickness, duration of disease, and Parkinson disease severity. Logistic regression analysis was performed to determine the most sensitive layer for predicting axonal atrophy.RESULTS: Parkinson disease patients showed statistically significant reduced thickness in the retinal nerve fiber, ganglion cell, inner plexiform, and outer plexiform layers and increased thickness in the inner nuclear layer compared with healthy subjects (P