Comparison of anti-inflammatory effects of intense pulsed light with tobramycin/dexamethasone plus warm compress on dry eye associated meibomian gland dysfunction
Comparison of anti-inflammatory effects of intense pulsed light with tobramycin/dexamethasone plus warm compress on dry eye associated meibomian gland dysfunction
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DOI：
10.18240/ijo.2019.11.07
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发表时间：
2019-11-18
影响因子：
1.4
通讯作者：
Qi, Hong
中科院分区：
文献类型：
--
作者：
Gao, Yu-Fei;Liu, Rong-Jun;Qi, Hong
目的：比较强脉冲光(IPL)与妥布霉素/地塞米松联合温敷对干眼病(DED)合并睑板腺功能障碍(MGD)患者的临床症状和泪液细胞因子的影响。A组采用IPL治疗，B组采用妥布霉素/地塞米松加温敷治疗。观察治疗前、治疗后1wk、1mo的眼表疾病指数(OSDI)、泪膜破裂时间(TBUT)、角膜荧光素染色(CFs)、睑板腺可表现性(MGE)、泪液质量、泪腺脱落及泪液细胞因子水平。结果：治疗后1mo，A组泪膜破裂时间高于B组(P=0.035)，MGE评分低于B组(P=0.001)。治疗后1wk，A组泪液中IL-17A和IL-1β水平的变化均低于B组(P=0.005，P=0.05)。结论：治疗1个月后，益气活血灵能改善DED合并MGD患者泪液中IL-17A和IL-1β的水平，降低泪液中IL-17A和IL-1β水平，优于妥布霉素/地塞米松加温敷治疗。
AIM: To compare the anti-inflammatory effects of intense pulsed light (IPL) with tobramycin/dexamethasone plus warm compress through clinical signs and cytokines in tears.METHODS: Eighty-two patients with dry eye disease (DED) associated meibomian gland dysfunction (MGD) were divided into two groups. Group A was treated with IPL, and Group B was treated with tobramycin/dexamethasone plus warm compress. Ocular Surface Disease Index (OSDI), tear film breakup time (TBUT), corneal fluorescein staining (CFS), meibomian gland expressibility (MGE), meibum quality, gland dropout and tear cytokine levels were evaluated before treatment, 1wk and 1 mo after treatment.RESULTS: TBUT in Group A was higher (P=0.035), and MGE score was lower than Group B at 1mo (P=0.001). The changes of interleukin (IL)-17A and IL-1 beta levels in tears were lower in Group A compared with that in Group B at 1wk after treatment (P=0.05, P=0.005).CONCLUSION: Treatment with IPL can improve TBUT and MGE and downregulate levels of IL-17A and IL-1 beta in tears of patients with DED associated MGD better than treatment with tobramycin/dexamethasone plus warm compress in one-month treatment period.