Restoration of Glucose Counterregulation by Islet Transplantation in Long-standing Type 1 Diabetes
Restoration of Glucose Counterregulation by Islet Transplantation in Long-standing Type 1 Diabetes
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DOI：
10.2337/db14-1620
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发表时间：
2015-05-01
期刊：
影响因子：
7.7
通讯作者：
Teff, Karen L.
中科院分区：
文献类型：
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作者：
Rickels, Michael R.;Fuller, Carissa;Teff, Karen L.
长期患有 1 型糖尿病 (T1D) 的患者可能表现出葡萄糖反调节缺陷和低血糖症状识别受损，从而大大增加了他们发生严重低血糖的风险。本研究的目的是确定肝内胰岛移植是否可以改善患有严重低血糖的 T1D 患者的低血糖反应中的内源性葡萄糖生成 (EGP)。我们使用阶梯式高胰岛素-低血糖钳和配对高胰岛素-正常钳夹并输注 6,6-H-2(2)-葡萄糖，对肝内胰岛移植前病程 30 年和病程 6 个月的受试者 (n = 12) 进行纵向研究，并将结果与非糖尿病对照组 (n = 8) 的结果进行比较。胰岛移植后，HbA(1c) 恢复正常，降血糖时间也恢复正常（
Patients with long-standing type 1 diabetes (T1D) may exhibit defective glucose counterregulation and impaired hypoglycemia symptom recognition that substantially increase their risk for experiencing severe hypoglycemia. The purpose of this study was to determine whether intrahepatic islet transplantation improves endogenous glucose production (EGP) in response to hypoglycemia in T1D patients experiencing severe hypoglycemia. We studied longitudinally subjects (n = 12) with,30 years, disease duration before and 6 months after intrahepatic islet transplantation using stepped hyperinsulinemic-hypoglycemic and paired hyperinsulinemic-euglycemic clamps with infusion of 6,6-H-2(2)-glucose and compared the results with those from a nondiabetic control group (n = 8). After islet transplantation, HbA(1c) was normalized, and time spent while hypoglycemic (