The impact of infection with human metapneumovirus and other respiratory viruses in young infants and children at high risk for severe pulmonary disease
The impact of infection with human metapneumovirus and other respiratory viruses in young infants and children at high risk for severe pulmonary disease
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DOI：
10.1086/503806
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发表时间：
2006-06-01
影响因子：
6.4
通讯作者：
Polack, FP
中科院分区：
文献类型：
--
作者：
Klein, MI;Coviello, S;Polack, FP
我们进行了一项前瞻性观察性研究，旨在描述布宜诺斯艾利斯 194 名患有慢性肺病或先天性心脏病的早产儿和幼儿中由人类偏肺病毒 (hMPV) 和其他病毒引起的呼吸道感染的临床表现。儿童有 567 次出现呼吸道疾病，并受到监测直至他们 2 岁或直至研究完成。 hMPV 全年引发 12 例感染 (2%)； 30% 的严重程度为中度或以上。人类副流感病毒 3 型导致 24 例感染（4%），20 例肺部感染中有 5 例（25%）需要住院治疗。呼吸道合胞病毒 (RSV) 在呼吸道季节引起了 33 次感染，占感染的 17% 和住院的 32%。感染流感病毒的10名儿童中，无一人病情严重。目前对高危儿童的研究表明，hMPV 和流感病毒是罕见的严重疾病病原体，并强调了在发展中国家针对 RSV 采取预防性干预措施的必要性。
We conducted a prospective, observational study to characterize the clinical manifestations of respiratory infections caused by human metapneumovirus (hMPV) and other viruses in 194 premature infants and young children with chronic lung disease or congenital heart disease in Buenos Aires. Children had 567 episodes of respiratory illness and were monitored until they were 2 years old or until the completion of the study. hMPV elicited 12 infections (2%) year-round; 30% were of moderate or greater severity. Human parainfluenza virus type 3 caused 24 infections (4%), and 5 (25%) of 20 lung infections led to hospitalization. Respiratory syncytial virus (RSV) caused 33 episodes-17% of infections and 32% of hospitalizations during the respiratory season. None of the 10 children infected with influenza virus had severe disease. The present study of at-risk children suggests that hMPV and influenza virus are infrequent agents of severe disease and highlights the need for preventive interventions against RSV in developing countries.