Group B Streptococcus and Escherichia coli Infections in the Intensive Care Nursery in the Era of Intrapartum Antibiotic Prophylaxis
Group B Streptococcus and Escherichia coli Infections in the Intensive Care Nursery in the Era of Intrapartum Antibiotic Prophylaxis
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DOI：
10.1097/inf.0b013e318275058a
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发表时间：
2013-03-01
影响因子：
3.6
通讯作者：
Cohen-Wolkowiez, Michael
中科院分区：
文献类型：
--
作者：
Bauserman, Melissa S.;Laughon, Matthew M.;Cohen-Wolkowiez, Michael
背景资料：B族链球菌（GBS）和大肠杆菌引起严重的细菌感染（SBI），并与新生儿的发病率和死亡率有关。产时抗生素预防可减少GBS引起的早发性SBI。分娩期抗生素预防对迟发性SBIs的影响引起这些organism.Methods：我们检查了所有的血液，尿液和脑脊液培养结果从1997年至2010年收治的婴儿322新生儿重症监护病房由Pediatrix医疗集团管理。我们确定了GBS或E培养阳性的婴儿。大肠杆菌，并比较了发病前一段时间内每种微生物的早发性和迟发性SBI的发生率。（1997年至2001年）及以后结果：我们确定了716，407名婴儿的培养，2520名（0.4%）GBS培养阳性，2476名（0.3%）E.杆菌1997年至2001年以及2002年至2010年间，GBS早发性SBI的发病率从每1000名入院者3.5例下降至2.6例，而E.大肠杆菌早发性SBI保持稳定（两个时间段均为1.4/1000）。在同一时期，GBS迟发性SBI的发病率从0.8/1000例增加到1.1/1000例，E。结论：在我们的队列中，GBS早发性SBI的发病率下降，而大肠杆菌迟发性SBI的发病率从2.2/1000例增加到2.5/1000例。大肠杆菌和GBS增加。
Background: Group B Streptococcus (GBS) and Escherichia coli cause serious bacterial infections (SBIs) and are associated with morbidity and mortality in newborn infants. Intrapartum antibiotic prophylaxis reduces early-onset SBIs caused by GBS. The effect of intrapartum antibiotic prophylaxis on late-onset SBIs caused by these organisms is unknown.Methods: We examined all blood, urine and cerebrospinal fluid culture results from infants admitted from 1997 to 2010 to 322 neonatal intensive care units managed by the Pediatrix Medical Group. We identified infants with positive cultures for GBS or E. coli and compared the incidence of early-and late-onset SBI for each organism in the time period before (1997 to 2001) and after (2002 to 2010) universal intrapartum antibiotic prophylaxis recommendations.Results: We identified 716,407 infants with cultures, 2520 (0.4%) with cultures positive for GBS and 2476 (0.3%) with cultures positive for E. coli. The incidence of GBS early-onset SBI decreased between 1997 to 2001 and 2002 to 2010 from 3.5 to 2.6 per 1000 admissions, and the incidence for E. coli early-onset SBI remained stable (1.4/1000 admissions in both time periods). Over the same time period, the incidence of GBS late-onset SBI increased from 0.8 to 1.1 per 1000 admissions, and incidence of E. coli -late-onset SBI increased from 2.2 to 2.5 per 1000 admissions.Conclusions: In our cohort, the incidence of GBS early-onset SBI decreased, whereas the incidence of late-onset SBI for E. coli and GBS increased.