Effect of bezafibrate therapy on atherosclerotic aortic plaques detected by MRI in dyslipidemic patients with hypertriglyceridemia
Effect of bezafibrate therapy on atherosclerotic aortic plaques detected by MRI in dyslipidemic patients with hypertriglyceridemia
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DOI：
10.1016/j.atherosclerosis.2006.11.035
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发表时间：
2008-01-01
期刊：
影响因子：
5.3
通讯作者：
Ohsuzu, Fumitaka
中科院分区：
文献类型：
--
作者：
Ayaori, Makoto;Momiyama, Yukihiko;Ohsuzu, Fumitaka
贝特类降低甘油三酯（TG）和增加HDL-胆固醇水平，但没有报告显示贝特类使斑块消退。使用MRI，我们研究了苯扎贝特对22例血脂异常患者主动脉斑块的影响。所有患者均接受400 mg苯扎贝特，但8名拒绝接受苯扎贝特的患者成为对照组。评价血管壁面积（VWA）和管腔面积（LA）从基线至1年的变化。苯扎贝特降低TG（-55%），增加HDL-胆固醇水平（+29%）。苯扎贝特降低HDL大小和增加LDL大小。在胸部斑块中，苯扎贝特降低了VWA（-6%，P <0.001），而LA无变化，但在无苯扎贝特的情况下VWA略有进展（+5%）。在腹部斑块中，苯扎贝特使VWA降低（-8%，P <0.001），LA增加（+3%，P <0.02），但在无苯扎贝特的情况下VWA进展（+6%）。胸腹部斑块中VWA的变化与TG降低和HDL-胆固醇升高相关。值得注意的是，仅腹部斑块中的VWA变化与HDL大小减少和LDL大小增加相关。因此，苯扎贝特诱导胸、腹主动脉粥样硬化斑块消退，TG显著降低，HDL-胆固醇显著升高，但胸、腹主动脉粥样硬化斑块消退和血管重塑过程可能不同。然而，由于我们的研究不是一个对照，随机试验，需要进一步的研究。(c)2006爱思唯尔爱尔兰有限公司保留所有权利。
Fibrates reduce triglycerides (TG) and increase HDL-cholesterol levels, but there was no report showing plaque regression by fibrates. Using MRI, we investigated the effects of bezafibrate on aortic plaques in 22 dyslipidemic patients. All patients were asked to receive 400 mg bezatibrate, but 8 who declined to have bezafibrate became the control group. Changes in vessel wall area (VWA) and lumen area (LA) from baseline to 1-year were evaluated. Bezafibrate reduced TG (-55%) and increased HDL-cholesterol levels (+29%). Bezafibrate reduced HDL size and increased LDL size. In thoracic plaques, bezafibrate reduced VWA (-6%, P < 0.001) with no LA change, but VWA slightly progressed without bezafibrate (+5%). In abdominal plaques, bezafibrate reduced VWA (-8%, P < 0.001) with LA increase (+3%, P < 0.02), but VWA progressed without bezafibrate (+6%). VWA changes in thoracic and abdominal plaques correlated with TG reduction and HDL-cholesterol increase. Notably, VWA change in only abdominal plaques correlated with HDL size reduction and LDL size increase. Thus, bezafibrate induced plaque regression in thoracic and abdominal aortas with marked TG reduction and HDL-cholesterol increase, but the processes of plaque regression and vascular remodeling may differ between thoracic and abdominal aortas. However, because our study was not a controlled, randomized trial, further study is needed. (c) 2006 Elsevier Ireland Ltd. All rights reserved.