NEW PERSPECTIVES ON A SUBCLINICAL FORM OF VISCERAL LEISHMANIASIS
NEW PERSPECTIVES ON A SUBCLINICAL FORM OF VISCERAL LEISHMANIASIS
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DOI：
10.1093/infdis/154.6.1003
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发表时间：
1986-12-01
影响因子：
6.4
通讯作者：
JOHNSON, WD
中科院分区：
文献类型：
--
作者：
BADARO, R;JONES, TC;JOHNSON, WD
在巴西一个流行地区对内脏利什曼病的流行病学研究中，对该疾病的亚临床形式出现了新的观点。检测出86例携带利什曼原虫抗体的儿童。这些儿童都没有利什曼病病史。儿童被分为四组：一组无症状（n = 20），而另一组在指标血清学数周内出现经典黑热病（n = 15）。其余51例患者最初患有亚临床疾病；其中13例（25%）发展为典型黑热病（平均5个月）。其余75%的患者在较长时间（平均35个月）后病情得到缓解。亚临床组的首发表现为肝肿大、频繁脾肿大、间歇性咳嗽、腹泻和低烧。身体不适和体重不增加是常见的。在没有典型黑热病症状的情况下，吉姆萨染色涂片和骨髓抽吸培养通常对利什曼原虫呈阴性。
During an epidemiological study of visceral leishmaniasis in an endemic region of Brazil, new perspectives emerged on a subclinical form of the disease. A group of 86 children with antibody to Leishmania were identified. None of these children had a history of leishmaniasis. The children were segregated into four groups: One group remained asymptomatic (n = 20), whereas another developed classic kala-azar within weeks of the index serology (n = 15). The remaining 51 patients initially had subclinical disease; 13 (25%) of these patients progressed to classic kala-azar (mean, five months). The others (75%) resolved their illness after a prolonged period (mean, 35 months). The initial illness in the subclinical group was characterized by hepatomegaly, frequent splenomegaly, intermittent cough, diarrhea, and low-grade fever. Malaise and poor weight gain were common. Giemsa-stained smears and cultures of bone marrow aspirates were usually negative for Leishmania in the absence of symptoms of classic kala-azar.