Molecular pathogenesis and therapeutic targets in epithelial ovarian cancer
Molecular pathogenesis and therapeutic targets in epithelial ovarian cancer
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DOI：
10.1002/jcb.21552
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发表时间：
2007-12-01
影响因子：
4
通讯作者：
Hartmann, Lynn C.
中科院分区：
文献类型：
--
作者：
Chien, Jeremy R.;Aletti, Giovanni;Hartmann, Lynn C.
卵巢癌是最具侵袭性的妇科癌症，是发达国家妇科恶性肿瘤的首要死亡原因。两个主要原因解释了其侵略性行为：大多数患者在诊断时表现为晚期疾病，并死于对常规化疗产生耐药性的疾病复发。在这篇关于上皮性卵巢癌（EOC）的文章中，我们将回顾与迄今为止发现的少数前体病变相关的分子改变，其次是更普遍认识的从头癌变、转移和化疗耐药的发展过程。我们将提出一个统一的模型卵巢上皮性肿瘤的发生，考虑到各种假设。我们还将审查新的方法，以克服卵巢癌化疗耐药的主要问题。最后，我们将讨论小鼠模型系统发展的进展和新挑战，以研究
Ovarian cancer, the most aggressive gynecologic cancer, is the foremost cause of death from gynecologic malignancies in the developed world. Two primary reasons explain its aggressive behavior: most patients present with advanced disease at diagnosis, and die of recurrences from disease that has become resistant to conventional chemotherapies. In this paper on epithelial ovarian cancer (EOC), we will review molecular alterations associated with the few precursor lesions identified to date, followed by the more commonly recognized processes of de novo carcinogenesis, metastasis, and the development of chemoresistance. We will propose a unifying model of ovarian epithelial tumorigenesis that takes into account various hypotheses. We will also review novel approaches to overcome the major problem of chemoresistance in ovarian cancer. Finally, we will discuss advances and new challenges in the development of mouse model systems to investigate