Efficacy and Safety of Curcuma domestica Extracts in Patients with Knee Osteoarthritis
Efficacy and Safety of Curcuma domestica Extracts in Patients with Knee Osteoarthritis
复制标题
DOI：
10.1089/acm.2008.0186
复制
发表时间：
2009-08-01
影响因子：
2.6
通讯作者：
Thamlikitkul, Visanu
中科院分区：
文献类型：
--
作者：
Kuptniratsaikul, Vilai;Thanakhumtorn, Sunee;Thamlikitkul, Visanu
目的：本研究的目的是确定姜黄提取物在减轻膝骨关节炎患者疼痛和改善功能方面的功效和安全性。研究设计和设置：设计和设置是在泰国曼谷的一所大学医院进行的随机对照研究。方法：一百零七 (107) 例疼痛评分 >= 5 的原发性膝骨关节炎 (OA) 患者随机接受布洛芬 800 mg 每天或姜黄治疗每天提取 2 克，持续 6 周。主要结果是平地行走疼痛、楼梯疼痛的改善，以及通过 100 米步行和上下楼梯所花费的时间评估膝盖功能。还记录了不良事件。 结果：五十二 (52) 名患者和 55 名患者分别随机分配至家蚕提取物组和布洛芬组。两组患者的基线特征没有差异。与两组基线值相比，第 0、2、4 和 6 周上述结果的平均得分均显着提高。除了楼梯疼痛外，接受布洛芬和家蝇提取物的患者之间的这些参数没有差异（p = 0.016）。两组之间的不良事件没有显着差异（家蝇提取物组和布洛芬组分别为 33.3% 和 44.2%，p = 0.36）。 结论：家蝇提取物似乎与布洛芬治疗膝关节骨关节炎具有相似的功效和安全性。
Objective: The objective of this study was to determine the efficacy and safety of Curcuma domestica extracts in pain reduction and functional improvement in patients with knee osteoarthritis.Study design and setting: The design and setting were a randomized controlled study at a university hospital in Bangkok, Thailand.Methods: One-hundred and seven (107) patients with primary knee osteoarthritis (OA) with pain score of >= 5 were randomized to receive ibuprofen 800 mg per day or C. domestica extracts 2 g per day for 6 weeks. The main outcomes were improvement in pain on level walking, pain on stairs, and functions of knee assessed by time spent during 100-m walk and going up and down a flight of stairs. The adverse events were also recorded.Results: Fifty-two (52) and 55 patients were randomized to C. domestica extracts and ibuprofen groups, respectively. Baseline characteristics of the patients in both groups were not different. The mean scores of the aforementioned outcomes at weeks 0, 2, 4, and 6 were significantly improved when compared with the baseline values in both groups. There was no difference in those parameters between the patients receiving ibuprofen and C. domestica extracts, except pain on stairs (p = 0.016). No significant difference of adverse events between both groups was found (33.3% versus 44.2%, p = 0.36 in C. domestica extracts and ibuprofen groups, respectively).Conclusions: C. domestica extracts seem to be similarly efficacious and safe as ibuprofen for the treatment of knee OA.