Soluble biomarkers of immune activation and inflammation in HIV infection: impact of 2 years of effective first-line combination antiretroviral therapy
Soluble biomarkers of immune activation and inflammation in HIV infection: impact of 2 years of effective first-line combination antiretroviral therapy
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DOI：
10.1111/hiv.12257
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发表时间：
2015-10-01
期刊：
影响因子：
3
通讯作者：
Katlama, C.
中科院分区：
文献类型：
--
作者：
Hattab, S.;Guiguet, M.;Katlama, C.
ObjectivesThe目的的研究是评估快速和持续的病毒控制的影响所产生的联合抗逆转录病毒治疗（cART）对艾滋病相关的免疫激活和inflammation.MethodsIn这项纵向观察研究中，我们检查了白细胞介素-6（IL-6），干扰素诱导蛋白-10（IP-10），在2年有效的一线cART治疗期间，干扰素（IFN-γ）诱导的单核因子和可溶性CD 14（sCD 14）水平。使用Wilcoxon符号秩检验，将cART前后的生物标志物水平与健康受试者中观察到的水平进行比较。相对于健康受试者的值（平均值± 2个标准差），定义了升高的生物标志物水平。通过logistic regression.ResultsWe纳入了139例患者，在cART启动[第0天（D 0）]时，中位HIV-1 RNA水平为4.8 log（10）HIV-1 RNA拷贝/mL，中位CD 4细胞计数为294 cells/L。D 0时，所有生物标志物水平均高于健康受试者（P
ObjectivesThe aim of the study was to assess the impact of rapid and sustained viral control produced by combination antiretroviral therapy (cART) on HIV-associated immune activation and inflammation.MethodsIn this longitudinal observational study, we examined changes in interleukin-6 (IL-6), interferon--inducible protein-10 (IP-10), monokine induced by interferon- (MIG) and soluble CD14 (sCD14) levels during 2 years of effective first-line cART. Biomarker levels before and after cART were compared with those observed in healthy subjects, using the Wilcoxon signed rank test. Elevated biomarker levels were defined with respect to values for healthy subject (mean + 2 standard deviations). Factors associated with persistently elevated biomarker levels after 2 years of cART were identified by logistic regression.ResultsWe included in the study 139 patients with a median HIV-1 RNA level of 4.8 log(10) HIV-1 RNA copies/mL and a median CD4 cell count of 294cells/L at cART initiation [day 0 (D0)]. At D0, all biomarker levels were higher than in healthy subjects (P