Reconfiguration of DNA methylation in aging
Reconfiguration of DNA methylation in aging
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DOI：
10.1016/j.mad.2015.02.002
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发表时间：
2015-11-01
影响因子：
5.3
通讯作者：
Caiafa, Paola
中科院分区：
文献类型：
--
作者：
Zampieri, Michele;Ciccarone, Fabio;Caiafa, Paola
多种生物效应之间复杂的相互作用塑造了衰老过程。全基因组定量方法在表观遗传学领域的出现，突出了表观遗传失调，特别是DNA甲基化，对衰老的有效影响。DNA甲基化中与启动子相关的改变通常被归类为称为“表观遗传漂变”的现象，其特征在于基因组的逐渐广泛的去甲基化和许多启动子相关的CpG岛的超甲基化。令人惊讶的是，特定的DNA区域在老年个体中显示出定向的表观遗传变化，这表明这些事件对衰老过程的重要性。然而，由于最近发现的5-羟甲基胞嘧啶，一个新的DNA表观遗传标记存在于基因组中，到目前为止，在衰老中获得的表观遗传信息需要重新考虑。概括的DNA甲基化的调控和发生在衰老的变化的因素将在这篇评论中也考虑到5 hmC的可用数据进行描述。(C)2015作者由Elsevier爱尔兰有限公司发布。这是CC BY-NC-ND许可证下的开放获取文章（http：//creativecommons.org/licenses/by-nc-nd/4.0/）。
A complex interplay between multiple biological effects shapes the aging process. The advent of genome-wide quantitative approaches in the epigenetic field has highlighted the effective impact of epigenetic deregulation, particularly of DNA methylation, on aging. Age-associated alterations in DNA methylation are commonly grouped in the phenomenon known as "epigenetic drift" which is characterized by gradual extensive demethylation of genome and hypermethylation of a number of promoter-associated CpG islands. Surprisingly, specific DNA regions show directional epigenetic changes in aged individuals suggesting the importance-of these events for the aging process. However, the epigenetic information obtained until now in aging needs a re-consideration due to the recent discovery of 5-hydroxymethylcytosine, a new DNA epigenetic mark present on genome. A recapitulation of the factors involved in the regulation of DNA methylation and the changes occurring in aging will be described in this review also considering the data available on 5hmC. (C) 2015 The Authors. Published by Elsevier Ireland Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).